Document Detail


Obesity and survival in population-based patients with pancreatic cancer in the San Francisco Bay Area.
MedLine Citation:
PMID:  23015286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Obesity has been consistently associated with increased risk of pancreatic cancer incidence and mortality. However, studies of obesity and overall survival in patients with pancreatic cancer are notably lacking, especially in population-based studies.
METHODS: Active and passive follow-up were used to determine vital status and survival for 510 pancreatic cancer patients diagnosed from 1995 to 1999 in a large population-based case-control study in the San Francisco Bay Area. Survival rates were computed using Kaplan-Meier methods. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated in multivariable Cox proportional hazards models as measures of the association between pre-diagnostic obesity and pancreatic cancer survival.
RESULTS: An elevated hazard ratio of 1.3 (95 % CI, 0.91-1.81) was observed for obese [body mass index (BMI) ≥ 30] compared with normal range BMI (<25) patients. Associations between BMI and overall survival did not statistically significantly vary by known prognostic and risk factors (all p-interaction ≥0.18), yet elevated HRs consistently were observed for obese compared with normal BMI patients [localized disease at diagnosis (HR, 3.1), surgical resection (HR, 1.6), ever smokers (HR, 1.6), diabetics (HR, 3.3)]. Poor survival was observed among men, older patients, more recent and current smokers, whereas improved survival was observed for Asian/Pacific Islanders.
CONCLUSIONS: Our results in general provide limited support for an association between pre-diagnostic obesity and decreased survival in patients with pancreatic cancer. Patterns of reduced survival associated with obesity in some patient subgroups could be due to chance and require assessment in larger pooled studies.
Authors:
Zhihong Gong; Elizabeth A Holly; Paige M Bracci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2012-09-27
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  23     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-07-09     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1929-37     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Body Mass Index
Female
Humans
Male
Middle Aged
Obesity / mortality*
Pancreatic Neoplasms / mortality*
Proportional Hazards Models
Risk Factors
SEER Program
San Francisco / epidemiology
Survival Rate
United States / epidemiology
Grant Support
ID/Acronym/Agency:
CA108370/CA/NCI NIH HHS; CA109767/CA/NCI NIH HHS; CA121846/CA/NCI NIH HHS; CA59706/CA/NCI NIH HHS; CA89726/CA/NCI NIH HHS; N01-PC-35136/PC/NCI NIH HHS; R01 CA109767/CA/NCI NIH HHS; R03 CA108370/CA/NCI NIH HHS; R03 CA121846/CA/NCI NIH HHS
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