| Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls. | |
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MedLine Citation:
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PMID: 17118995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree of these abnormalities remain unclear. OBJECTIVE: The objective of the study was to assess the degree of hyperandrogenemia across puberty in obese girls and assess overnight sex steroid changes in Tanner stage 1-3 girls. DESIGN: This was a cross-sectional analysis. SETTING: The study was conducted at general clinical research centers. SUBJECTS: Thirty normal-weight (body mass index for age < 85%) and 74 obese (body mass index for age >or= 95%) peripubertal girls. INTERVENTION: Blood samples (circa 0500-0700 h) were taken while fasting. Samples from the preceding evening (circa 2300 h) were obtained in 23 Tanner 1-3 girls. MAIN OUTCOME MEASURES: Hormone concentrations stratified by Tanner stage were measured. RESULTS: Compared with normal-weight girls, mean free testosterone (T) was elevated 2- to 9-fold across puberty in obese girls, whereas fasting insulin was 3-fold elevated in obese Tanner 1-3 girls (P < 0.05). Mean LH was lower in obese Tanner 1 and 2 girls (P < 0.05) but not in more mature girls. In a subgroup of normal-weight Tanner 1-3 girls (n = 17), mean progesterone (P) and T increased overnight 2.3- and 2.4-fold, respectively (P <or= 0.001). In obese Tanner 1-3 girls (n = 6), evening P and T were elevated, and both tended to increase overnight [mean 1.4- and 1.6-fold, respectively (P = 0.06)]. CONCLUSIONS: Peripubertal obesity is associated with hyperandrogenemia and hyperinsulinemia throughout puberty, being especially marked shortly before and during early puberty. P and T concentrations in normal-weight Tanner 1-3 girls increase overnight, with similar but less evident changes in obese girls. |
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Authors:
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Christopher R McCartney; Susan K Blank; Kathleen A Prendergast; Sandhya Chhabra; Christine A Eagleson; Kristin D Helm; Richard Yoo; R Jeffrey Chang; Carol M Foster; Sonia Caprio; John C Marshall |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-11-21 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 92 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-07 Completed Date: 2007-03-15 Revised Date: 2013-06-07 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 430-6 Citation Subset: AIM; IM |
Affiliation:
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Center for Research in Reproduction, Box 800391, University of Virginia Health System, Charlottesville, Virginia 22908, USA. cm2hq@virginia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Body Weight Child Circadian Rhythm Cross-Sectional Studies Female Humans Hydrocortisone / blood Hyperandrogenism / metabolism*, physiopathology Hyperinsulinism / metabolism, physiopathology Insulin / blood Obesity / metabolism*, physiopathology Progesterone / blood Puberty / blood* Testosterone / blood* |
| Grant Support | |
ID/Acronym/Agency:
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F32 HD042895-02/HD/NICHD NIH HHS; F32-HD-DK42895/DK/NIDDK NIH HHS; K23 HD044742/HD/NICHD NIH HHS; K23 HD044742-04/HD/NICHD NIH HHS; K23-HD-044742/HD/NICHD NIH HHS; M01 RR000125-38/RR/NCRR NIH HHS; M01 RR000827-31/RR/NCRR NIH HHS; M01 RR000847-33/RR/NCRR NIH HHS; M01-RR-00042/RR/NCRR NIH HHS; M01-RR-00827/RR/NCRR NIH HHS; M01-RR-00847/RR/NCRR NIH HHS; M01-RR00125/RR/NCRR NIH HHS; R01 HD040787-07/HD/NICHD NIH HHS; R01-HD-40787/HD/NICHD NIH HHS; T32 HD007382-17/HD/NICHD NIH HHS; T32-HD-07382/HD/NICHD NIH HHS; U54 HD012303/HD/NICHD NIH HHS; U54 HD012303-25A1/HD/NICHD NIH HHS; U54 HD012303-25A10011/HD/NICHD NIH HHS; U54 HD012303-25A1S1/HD/NICHD NIH HHS; U54 HD012303-26/HD/NICHD NIH HHS; U54 HD028934-14/HD/NICHD NIH HHS; U54-HD-12303/HD/NICHD NIH HHS; U54-HD-28934/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin; 50-23-7/Hydrocortisone; 57-83-0/Progesterone; 58-22-0/Testosterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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