Document Detail

Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls.
MedLine Citation:
PMID:  17118995     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree of these abnormalities remain unclear.
OBJECTIVE: The objective of the study was to assess the degree of hyperandrogenemia across puberty in obese girls and assess overnight sex steroid changes in Tanner stage 1-3 girls.
DESIGN: This was a cross-sectional analysis.
SETTING: The study was conducted at general clinical research centers.
SUBJECTS: Thirty normal-weight (body mass index for age < 85%) and 74 obese (body mass index for age >or= 95%) peripubertal girls.
INTERVENTION: Blood samples (circa 0500-0700 h) were taken while fasting. Samples from the preceding evening (circa 2300 h) were obtained in 23 Tanner 1-3 girls.
MAIN OUTCOME MEASURES: Hormone concentrations stratified by Tanner stage were measured.
RESULTS: Compared with normal-weight girls, mean free testosterone (T) was elevated 2- to 9-fold across puberty in obese girls, whereas fasting insulin was 3-fold elevated in obese Tanner 1-3 girls (P < 0.05). Mean LH was lower in obese Tanner 1 and 2 girls (P < 0.05) but not in more mature girls. In a subgroup of normal-weight Tanner 1-3 girls (n = 17), mean progesterone (P) and T increased overnight 2.3- and 2.4-fold, respectively (P <or= 0.001). In obese Tanner 1-3 girls (n = 6), evening P and T were elevated, and both tended to increase overnight [mean 1.4- and 1.6-fold, respectively (P = 0.06)].
CONCLUSIONS: Peripubertal obesity is associated with hyperandrogenemia and hyperinsulinemia throughout puberty, being especially marked shortly before and during early puberty. P and T concentrations in normal-weight Tanner 1-3 girls increase overnight, with similar but less evident changes in obese girls.
Christopher R McCartney; Susan K Blank; Kathleen A Prendergast; Sandhya Chhabra; Christine A Eagleson; Kristin D Helm; Richard Yoo; R Jeffrey Chang; Carol M Foster; Sonia Caprio; John C Marshall
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-11-21
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  92     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-03-15     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  430-6     Citation Subset:  AIM; IM    
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MeSH Terms
Body Weight
Circadian Rhythm
Cross-Sectional Studies
Hydrocortisone / blood
Hyperandrogenism / metabolism*,  physiopathology
Hyperinsulinism / metabolism,  physiopathology
Insulin / blood
Obesity / metabolism*,  physiopathology
Progesterone / blood
Puberty / blood*
Testosterone / blood*
Grant Support
F32 HD042895-02/HD/NICHD NIH HHS; F32-HD-DK42895/DK/NIDDK NIH HHS; K23 HD044742/HD/NICHD NIH HHS; K23 HD044742-04/HD/NICHD NIH HHS; K23-HD-044742/HD/NICHD NIH HHS; M01 RR000125-38/RR/NCRR NIH HHS; M01 RR000827-31/RR/NCRR NIH HHS; M01 RR000847-33/RR/NCRR NIH HHS; M01-RR-00042/RR/NCRR NIH HHS; M01-RR-00827/RR/NCRR NIH HHS; M01-RR-00847/RR/NCRR NIH HHS; M01-RR00125/RR/NCRR NIH HHS; R01 HD040787/HD/NICHD NIH HHS; R01 HD040787-07/HD/NICHD NIH HHS; R01-HD-40787/HD/NICHD NIH HHS; T32 HD007203/HD/NICHD NIH HHS; T32 HD007382/HD/NICHD NIH HHS; T32 HD007382-17/HD/NICHD NIH HHS; T32-HD-07382/HD/NICHD NIH HHS; U54 HD012303/HD/NICHD NIH HHS; U54 HD012303-25A1/HD/NICHD NIH HHS; U54 HD012303-25A10011/HD/NICHD NIH HHS; U54 HD012303-25A1S1/HD/NICHD NIH HHS; U54 HD012303-26/HD/NICHD NIH HHS; U54 HD028934/HD/NICHD NIH HHS; U54 HD028934-14/HD/NICHD NIH HHS; U54-HD-12303/HD/NICHD NIH HHS; U54-HD-28934/HD/NICHD NIH HHS
Reg. No./Substance:
0/Insulin; 3XMK78S47O/Testosterone; 4G7DS2Q64Y/Progesterone; WI4X0X7BPJ/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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