Document Detail


Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors.
MedLine Citation:
PMID:  23830106     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To analyze the reproductive outcome of recipients of donated ova according to their body mass index (BMI).
DESIGN: Twelve-year retrospective cohort analysis.
SETTING: Fertility clinics.
PATIENT(S): 9,587 first cycles of ovum donation with ova from normoweight donors.
INTERVENTION(S): Recipients divided according to their BMI to analyze IVF laboratory and outcome parameters: lean with BMI <20 kg/m(2) (n = 1,458; 15.2%); normoweight with BMI 20-24.9 kg/m(2) (n = 5,706; 59.5%), overweight with BMI 25-29.9 kg/m(2) (n = 1,770; 18.5%), and obese with BMI ≥30 kg/m(2) (n = 653; 6.8%).
MAIN OUTCOME MEASURE(S): Implantation, biochemical and clinical pregnancy, miscarriage, and live-birth rates.
RESULT(S): In vitro fertilization laboratory parameters did not differ according to BMI. However, implantation, pregnancy, clinical pregnancy, twin pregnancy, and live-birth rates were significantly reduced as BMI increased. In the lean, normoweight, overweight, and obese groups, the implantation rate was 40.4%, 39.9%, 38.5%, and 30.9%, clinical pregnancy rate was 56.9%, 55.9%, 54.3%, and 45.3%, and live-birth rate was 38.6%, 37.9%, 34.9%, and 27.7%, respectively. However, clinical miscarriage rates were similar in all the groups.
CONCLUSION(S): Female obesity impairs the reproductive outcome of ovum donation probably as a result of reduced uterine receptivity.
Authors:
José Bellver; Antonio Pellicer; Juan Antonio García-Velasco; Agustín Ballesteros; José Remohí; Marcos Meseguer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-3
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Instituto Valenciano de Infertilidad, University of Valencia, Valencia, Spain. Electronic address: Jose.Bellver@ivi.es.
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