Document Detail


Obesity, pregnancy, inflammation, and vascular function.
MedLine Citation:
PMID:  20215337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal obesity is associated with increased morbidity and mortality for both mother and offspring. The mechanisms underlying the increased risk associated with maternal obesity are not well understood. In non-pregnant populations, many of the complications of obesity are thought to be mediated in part by inflammation and its sequelae. Recent studies suggest that a heightened inflammatory response may also be involved in mediating adverse clinical outcomes during pregnancy. This review summarizes our current knowledge about adipose tissue biology, and its role as an endocrine and inflammatory organ. The evidence for inflammation as a key mediator of adverse pregnancy outcome is also presented, focusing on the role of inflammation in adipose tissue, systemic inflammation, the placenta, and vascular endothelium.
Authors:
F C Denison; K A Roberts; S M Barr; J E Norman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-09
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  140     ISSN:  1741-7899     ISO Abbreviation:  Reproduction     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  373-85     Citation Subset:  IM    
Affiliation:
Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK. fiona.denison@ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism,  physiopathology*
Endothelium, Vascular / physiopathology
Female
Fibrinolysis
Humans
Inflammation / etiology*,  metabolism,  physiopathology
Inflammation Mediators / metabolism
Obesity / complications*,  metabolism,  physiopathology
Pregnancy
Pregnancy Complications / etiology*,  metabolism,  physiopathology
Pregnancy Complications, Cardiovascular / etiology*,  metabolism,  physiopathology
Pregnancy Outcome
Risk Factors
Chemical
Reg. No./Substance:
0/Inflammation Mediators

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