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Obesity is the predominant predictor of impaired glucose tolerance and metabolic disturbance in polycystic ovary syndrome.
MedLine Citation:
PMID:  22497305     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To evaluate the contribution to glucose intolerance and metabolic syndrome of obesity combined with the diagnostic criteria of polycystic ovary syndrome (PCOS). Design. Prospective study. Setting. University teaching hospital from August 31, 2010 to August 31, 2011. Population. Two hundred and twenty women with PCOS and seventy normal controls. Methods. The clinical and biochemical characteristics of women with PCOS and controls were evaluated. Main outcome measures. The impact of obesity, hyperandrogenism, oligo-anovulation, and polycystic ovary morphology on impaired glucose tolerance and metabolic disturbances. Results. Obese women with PCOS had significantly higher insulin resistance than obese normal controls. Logistic regression analysis showed that obesity was the only factor that predicts impaired glucose tolerance and metabolic syndrome. Use of the area under the receiver operating characteristic curve (AUROC) for the body mass index to predict impaired glucose tolerance and metabolic syndrome was more accurate than AUROCs for serum total testosterone levels and the average menstrual interval. Conclusions. Body weight status was the major factor determining the risk of impaired glucose tolerance and metabolic syndrome in women with PCOS. Obesity should be treated as the major factor determining long-term health consequences associated with PCOS.
Authors:
So-Jung Liang; Tsan-Hon Liou; Hui-Wen Lin; Chun-Sen Hsu; Chii-Ruey Tzeng; Ming-I Hsu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-12
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors AOGS© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
1Department of Obstetrics and Gynecology, Wan Fang Hospital, Taipei Medical University, Taipei 2Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei 3Department of Mathematics, Soochow University, Taipei 4Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
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