Document Detail


Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention.
MedLine Citation:
PMID:  19687163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: We sought to investigate the impact of body mass index (BMI) on long-term all-cause mortality in patients following first-time elective percutaneous coronary intervention (PCI).
METHODS AND RESULTS: We used the Scottish Coronary Revascularisation Register to undertake a cohort study of all patients undergoing elective PCI in Scotland between April 1997 and March 2006 inclusive. We excluded patients who had previously undergone revascularization. There were 219 deaths within 5 years of 4880 procedures. Compared with normal weight individuals, those with a BMI > or =27.5 and <30 were at reduced risk of dying (HR 0.59, 95% CI 0.39-0.90, 95%, P = 0.014). There was no attenuation of the association after adjustment for potential confounders, including age, hypertension, diabetes, and left ventricular function (adjusted HR 0.59, 95% CI 0.39-0.90, P = 0.015), and there were no statistically significant interactions. The results were unaltered by restricting the analysis to events beyond 30 days of follow-up.
CONCLUSION: Among patients undergoing percutaneous intervention for coronary artery disease, increased BMI was associated with improved 5 year survival. Among those with established coronary disease, the adverse effects of excess adipose tissue may be offset by beneficial vasoactive properties.
Authors:
Claire E Hastie; Sandosh Padmanabhan; Rachel Slack; Alastair C H Pell; Keith G Oldroyd; Andrew D Flapan; Kevin P Jennings; John Irving; Hany Eteiba; Anna F Dominiczak; Jill P Pell
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-08-17
Journal Detail:
Title:  European heart journal     Volume:  31     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-15     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  222-6     Citation Subset:  IM    
Affiliation:
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Balloon, Coronary / mortality*
Body Mass Index
Coronary Artery Disease / complications,  mortality,  therapy*
Female
Humans
Hypertension / complications,  mortality
Male
Middle Aged
Obesity / complications*
Risk Factors
Scotland / epidemiology
Grant Support
ID/Acronym/Agency:
//British Heart Foundation; //Chief Scientist Office
Comments/Corrections
Comment In:
Eur Heart J. 2010 Jan;31(2):146-8   [PMID:  19734553 ]
Rev Clin Esp. 2010 Sep;210(8):411-2   [PMID:  20580352 ]

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