| Obesity-induced glomerular hyperfiltration: its involvement in the pathogenesis of tubular sodium reabsorption. | |
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MedLine Citation:
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PMID: 18622024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Obesity is associated with hypertension and glomerular hyperfiltration. A major mechanism responsible for the obesity-associated hypertension is renal salt retention. An increased glomerular filtration fraction (FF) is expected to raise postglomerular oncotic pressure and to increase proximal tubular sodium reabsorption. The aim of the present study was to verify whether obesity-associated hyperfiltration leads to increased postglomerular oncotic pressure and increased proximal sodium reabsorption. METHODS: Twelve obese subjects (BMI >36) and 19 lean subjects participated in the study. They underwent measurement of glomerular filtration rate (GFR), renal plasma flow (RPF) and fractional excretion of lithium (FE Li). RESULTS: GFR, RPF and FF were 61%, 28% and 29% higher, respectively, in the obese than in the control group (P < 0.00001 for GFR, P < 0.005 for RPF and P < 0.00005 for FF). Half of the obese group had increased FF with increased GFR, while the other half had normal FF with high-normal or increased GFR. Postglomerular oncotic pressure was 13% higher (P < 0.03) and FE Li was 33% lower (P < 0.005) in the obese group with high FF than in the lean group. Postglomerular oncotic pressure and FE Li were normal in the obese group with normal FF. CONCLUSIONS: These results suggest that glomerular hyperfiltration may lead to increased proximal tubular sodium reabsorption in the obese. |
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Authors:
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Avry Chagnac; Michal Herman; Boris Zingerman; Arie Erman; Benaya Rozen-Zvi; Judith Hirsh; Uzi Gafter |
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Publication Detail:
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Type: Journal Article Date: 2008-07-12 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 23 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-25 Completed Date: 2009-03-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 3946-52 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Rabin Medical Center-Hasharon Hospital, Petah Tikva 49372, Israel. chagnac@clalit.org.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Glomerular Filtration Rate Humans Hypertension / etiology, physiopathology Kidney Glomerulus / physiopathology* Kidney Tubules, Proximal / physiopathology* Lithium / urine Male Middle Aged Obesity / complications, physiopathology* Renal Plasma Flow Young Adult |
| Chemical | |
Reg. No./Substance:
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7439-93-2/Lithium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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