Document Detail

Obesity-induced glomerular hyperfiltration: its involvement in the pathogenesis of tubular sodium reabsorption.
MedLine Citation:
PMID:  18622024     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Obesity is associated with hypertension and glomerular hyperfiltration. A major mechanism responsible for the obesity-associated hypertension is renal salt retention. An increased glomerular filtration fraction (FF) is expected to raise postglomerular oncotic pressure and to increase proximal tubular sodium reabsorption. The aim of the present study was to verify whether obesity-associated hyperfiltration leads to increased postglomerular oncotic pressure and increased proximal sodium reabsorption. METHODS: Twelve obese subjects (BMI >36) and 19 lean subjects participated in the study. They underwent measurement of glomerular filtration rate (GFR), renal plasma flow (RPF) and fractional excretion of lithium (FE Li). RESULTS: GFR, RPF and FF were 61%, 28% and 29% higher, respectively, in the obese than in the control group (P < 0.00001 for GFR, P < 0.005 for RPF and P < 0.00005 for FF). Half of the obese group had increased FF with increased GFR, while the other half had normal FF with high-normal or increased GFR. Postglomerular oncotic pressure was 13% higher (P < 0.03) and FE Li was 33% lower (P < 0.005) in the obese group with high FF than in the lean group. Postglomerular oncotic pressure and FE Li were normal in the obese group with normal FF. CONCLUSIONS: These results suggest that glomerular hyperfiltration may lead to increased proximal tubular sodium reabsorption in the obese.
Avry Chagnac; Michal Herman; Boris Zingerman; Arie Erman; Benaya Rozen-Zvi; Judith Hirsh; Uzi Gafter
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Publication Detail:
Type:  Journal Article     Date:  2008-07-12
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  23     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  3946-52     Citation Subset:  IM    
Department of Nephrology, Rabin Medical Center-Hasharon Hospital, Petah Tikva 49372, Israel.
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MeSH Terms
Case-Control Studies
Glomerular Filtration Rate
Hypertension / etiology,  physiopathology
Kidney Glomerulus / physiopathology*
Kidney Tubules, Proximal / physiopathology*
Lithium / urine
Middle Aged
Obesity / complications,  physiopathology*
Renal Plasma Flow
Young Adult
Reg. No./Substance:

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