Document Detail


Obesity impairs wound healing in ovariectomized female mice.
MedLine Citation:
PMID:  19567384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is increasing worldwide. Estrogen protects female mice from gaining weight in contrast to ovariectomy. Excess weight can inhibit wound healing. We determine the effects of obesity on wound healing in the presence and absence of estrogen. For this purpose, we generated (ovariectomized (OVX) and non-ovariectomized (NOVX)) lean mice by feeding a 30% calorie-restricted diet (CR), overweight mice a low-fat (LF) diet and obese mice a high-fat (HF) diet. CR mice had the lowest, LF an intermediate, and HF mice the highest body weights. OVX exacerbated weight gain in female mice. Wounds healed fastest in CR mice regardless of estrogen status. Contrastingly, wound healing in OVX obese female mice was delayed. In sum, OVX increased the propensity of gaining weight, CR mice healed wounds more rapidly than obese mice irrespective of estrogen status, and obesity in the absence of estrogen impaired wound healing.
Authors:
Valerie B Holcomb; Victoria A Keck; J Carl Barrett; Jina Hong; Steven K Libutti; Nomeli P Nunez
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  23     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  515-8     Citation Subset:  IM    
Affiliation:
The University of Texas at Austin, School of Human Ecology, Department of Nutritional Sciences, 1 University Station A2703, PAI 5.14, Austin, Texas 78712, U.S.A.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / physiology
Animals
Body Weight
Diet, Fat-Restricted
Dietary Fats / pharmacology
Energy Intake
Estrogens / physiology*
Female
Mice
Mice, Inbred C57BL
Obesity / physiopathology*
Ovariectomy*
Wound Healing / physiology*
Grant Support
ID/Acronym/Agency:
1K22CA127519-01A1/CA/NCI NIH HHS; ES007784/ES/NIEHS NIH HHS; ES09145/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Estrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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