Document Detail


Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.
MedLine Citation:
PMID:  19692490     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake.
OBJECTIVES: We investigated whether the recently reported obesity loci are associated with measures of abdominal adiposity and whether these variants affect dietary energy or macronutrient intake.
DESIGN: We studied 1700 female Dutch participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Their anthropometric measurements and intake of macronutrients were available. Genotyping was performed by using KASPar chemistry. A linear regression model, with an assumption of an additive effect, was used to analyze the association between genotypes of 12 single nucleotide polymorphisms (SNPs) and adiposity measures and dietary intake.
RESULTS: Seven SNPs were associated (P < 0.05) with weight, body mass index (BMI), and waist circumference (unadjusted for BMI). They were in or near to 6 loci: FTO, MC4R, KCTD15, MTCH2, NEGR1, and BDNF. Five SNPs were associated with dietary intake (P < 0.05) and were in or near 5 loci: SH2B1 (particularly with increased fat), KCTD15 (particularly with carbohydrate intake), MTCH2, NEGR1, and BDNF.
CONCLUSIONS: We confirmed some of the findings for the newly identified obesity loci that are associated with general adiposity in a healthy Dutch female population. Our results suggest that these loci are not specifically associated with abdominal adiposity but more generally with obesity. We also found that some of the SNPs were associated with macronutrient-specific food intake.
Authors:
Florianne Bauer; Clara C Elbers; Roger Ah Adan; Ruth Jf Loos; N Charlotte Onland-Moret; Diederick E Grobbee; Jana V van Vliet-Ostaptchouk; Cisca Wijmenga; Yvonne T van der Schouw
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-19
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-10-09     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  951-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat
Adiposity / genetics*
Aged
Body Mass Index
Body Weight / genetics*
Diet*
Energy Intake
Female
Food Preferences
Genome-Wide Association Study
Humans
Middle Aged
Netherlands / epidemiology
Obesity / epidemiology,  genetics*
Polymorphism, Single Nucleotide*
Waist Circumference / genetics*
Grant Support
ID/Acronym/Agency:
MC_U106188470//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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