Document Detail

Obesity decreases time to claudication and delays post-exercise hemodynamic recovery in elderly peripheral arterial disease patients.
MedLine Citation:
PMID:  18784409     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Althoughobesity is usually observed in peripheral arterial disease (PAD) patients, the effects of the association between these diseases on walking capacity are not well documented. OBJECTIVE: The main objectives of this study were to determine the effects of obesity on exercise tolerance and post-exercise hemodynamic recovery in elderly PAD patients. METHODS: 46 patients with stable symptoms of intermittent claudication were classified according to their body mass index (BMI) into normal group (NOR) = BMI <28.0 and obese or in risk of obesity group (OBE) = BMI >or=28.0. All patients performed a progressive graded treadmill test. During exercise, ventilatory responses were evaluated and pre- and post-exercise ankle and arm blood pressures were measured. RESULTS: Exercise tolerance and oxygen consumption at total walking time were similar between OBE and NOR. However, OBE showed a lower claudication time (309 +/- 151 vs. 459 +/- 272 s, p = 0.02) with a similar oxygen consumption at this time. In addition, OBE presented a longer time for ankle brachial index recovery after exercise (7.8 +/- 2.8 vs. 6.3 +/- 2.6 min, p = 0.02). CONCLUSION: Obesity in elderly PAD patients decreased time to claudication, and delayed post-exercise hemodynamic recovery. These results suggest that muscle metabolic demand, and not total workload, is responsible for the start of the claudication and maximal exercise tolerance in PAD patients. Moreover, claudication duration might be responsible for the time needed to a complete hemodynamic recovery after exercise.
Raphael Mendes Ritti Dias; Cláudia Lúcia de Moraes Forjaz; Gabriel Grizzo Cucato; Luis Augusto Riani Costa; Lucas Caseri Câmara; Nelson Wolosker; Maria de Fátima Nunes Marucci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-11
Journal Detail:
Title:  Gerontology     Volume:  55     ISSN:  1423-0003     ISO Abbreviation:  Gerontology     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-02     Revised Date:  2009-11-23    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Nutrition Department, Faculty of Public Health, University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Exercise Test
Intermittent Claudication / etiology*,  physiopathology*
Middle Aged
Obesity / complications*,  physiopathology*
Oxygen Consumption
Peripheral Vascular Diseases / complications*,  physiopathology*

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