Document Detail

Obesity at Conception Programs the Opioid System in the Offspring Brain.
MedLine Citation:
PMID:  23924601     Owner:  NLM     Status:  Publisher    
Maternal obesity during pregnancy increases the risk for offspring obesity, in part through effects on the developing brain. Previous research has shown that perinatal consumption of highly palatable foods by the mother can influence the development of offspring taste preferences and alter gene expression within the central nervous system (CNS) reward system. Opioids stimulate consumption of both fats and carbohydrates, and overconsumption of these energy dense foods increases the risk for obesity. What has remained unclear is whether this risk can be transmitted to the offspring prior to gestation or if it is wholly the gestational exposure that affects offspring brain development. Utilizing an embryo transfer experimental design, 2-cell embryos were obtained from obese or control dams, and transferred to obese or control gestational carriers. Expression of the mu-opioid receptor (MOR), preproenkephalin (PENK) and the dopamine transporter were evaluated in the hypothalamus and reward circuitry (ventral tegmental area, prefrontal cortex and nucleus accumbens) in adult and late embryonic brains. Obesity prior to pregnancy altered expression levels of both MOR and PENK, with males relatively more affected than females. These data are the first to demonstrate that obesity at conception, in addition to during gestation, can program the brain reward system.Neuropsychopharmacology accepted article preview online, 8 August 2013. doi:10.1038/npp.2013.193.
Nicola M Grissom; Randolph Lyde; Lori Christ; Isaac E Sasson; Jesselea Carlin; Alexa P Vitins; Rebecca A Simmons; Teresa M Reyes
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-08
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  -     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania [2] Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania.
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