| Obesity and asthma: co-morbidity or causal relationship? | |
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MedLine Citation:
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PMID: 21214041 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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There is substantial evidence that obesity and asthma are related. "Obese asthma" may be a unique phenotype of asthma, characterized by decreased lung volumes, greater symptoms for a given degree of lung function impairment, destabilization or lack of asthma control, lack of eosinophilic inflammation and a different response to controller medication. Whether this relationship between obesity and asthma is causal or represents co-morbidity due to other factors is unclear. In previous reviews concerning the relationship between obesity and asthma, five hypotheses were put forth. One of these hypotheses is that a low grade systemic inflammation caused by adipokines from the fat tissue causes or enhances bronchial inflammation. In animal models, there is an increasing amount of evidence for the role of adipokines derived from fat tissue in the relationship between obesity and asthma. The data are conflicting in humans. Since obesity is a component of the metabolic syndrome and the metabolic syndrome is also a form of systemic inflammation, it is to be expected that there is a relationship between metabolic syndrome and asthma. The few data that are available show that there is no relationship between metabolic syndrome and asthma, but there is one between the metabolic syndrome and asthma-like symptoms. Further research is needed to confirm the relationship between obesity and asthma in humans, where a rigorous approach in the diagnosis of asthma is essential. |
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Authors:
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A van Huisstede; G J Braunstahl |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo Volume: 73 ISSN: 1122-0643 ISO Abbreviation: Monaldi Arch Chest Dis Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2011-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307314 Medline TA: Monaldi Arch Chest Dis Country: Italy |
Other Details:
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Languages: eng Pagination: 116-23 Citation Subset: IM |
Affiliation:
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Sint Franciscus Gasthuis, Secretariaat Maatschap Interne Geneeskunde, Kleiweg 500, 3045 PM Rotterdam, The Netherlands. a.vanhuisstede@sfg.nl |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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