Document Detail

Obesity is associated with an altered autonomic nervous system response to nutrient restriction.
MedLine Citation:
PMID:  23252937     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Heart rate variability (HRV) reflects the balance of activities of sympathetic and parasympathetic components of the autonomic nervous system. We compared HRV parameters in response to a prolonged fast in obese versus normal weight humans. In addition, the effect of weight-loss was evaluated in obese individuals. DESIGN: Intervention study PATIENTS: 14 non-diabetic obese (12 females/2 males, aged 30 ± 3 years, Body Mass Index (BMI) 35.2 ± 1.2 kg/m(2) ) and 12 lean subjects(10 females/2 males, aged 27 ± 3 years, BMI of 23.3 ± 0.5 kg/m(2) ) MEASUREMENTS: HRV was examined 75 minutes after standardized breakfast and after a 48h fast in 14 non-diabetic obese and 12 lean subjects. The postprandial measurement was repeated in 12 obese subjects after weight-loss. RESULTS: In lean subjects, fasting decreased high frequency (HF) power by 43% (p<0.05) and decreased low frequency (LF) power by 37% (p=0.1), leaving the LF/HF ratio unchanged (p=0.7). In the obese group, autonomic nervous system tone shifted to sympathetic dominance as the LF/HF increased from 0.61 to 1.14 (p=0.03). After an average weight-loss of 13.8 kg in obese subjects, a trend for sympathetic dominance was found; the LF/HF ratio increased by 56% (p=0.06). CONCLUSION: Our data show that a 48h fast leaves autonomic nervous system balance unaltered in lean subjects. In contrast, a 48h fast as well as weight-loss induce sympathetic dominance in obese humans. © 2012 Blackwell Publishing Ltd.
M A Wijngaarden; H Pijl; K Willems van Dijk; E S Klaassen; J Burggraaf
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-18
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Department of Endocrinology & Metabolism, Leiden University Medical Center.
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