| Obesity-associated genetic variants in young Asian Indians with the metabolic syndrome and myocardial infarction. | |
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MedLine Citation:
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PMID: 21298202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Associations between obesity-related polymorphisms and the metabolic syndrome in 485 young ( ≤ 45 Years) Asian Indian patients with acute myocardial infarction (AMI), and 300 matched controls were assessed. METHODS: Genetic variants included the adiponectin 45T→G and 276G→T, LEPR K109R and Q223R, MC4R-associated C→T and FTO A→T polymorphisms. RESULTS: The metabolic syndrome, as defined by NCEP ATP III and IDF criteria, was diagnosed in 61 and 60% of patients, respectively. No relationship was found between the obesity-associated polymorphisms and the metabolic syndrome, or between AMI patients and controls. The MC4R-associated TT genotype occurred more frequently in patients with lower triglyceride levels (p = 0.024), while the adiponectin 45 TT genotype occurred more commonly in patients with normal fasting glucose levels (p = 0.004). The LEPR Q223R TT genotype was associated with low high-density lipoprotein (HDL) cholesterol levels (p = 0.003). CONCLUSION: The metabolic syndrome occurs commonly in young Asian Indian patients with AMI. No relationship was found between any obesity-associated polymorphism and the metabolic syndrome. Particular genotypes may exert protective or disadvantageous effects on individual components of the metabolic syndrome. |
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Authors:
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N Ranjith; R J Pegoraro; R Shanmugam |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular journal of Africa Volume: 22 ISSN: 1995-1892 ISO Abbreviation: Cardiovasc J Afr Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-02-07 Completed Date: 2011-04-06 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 101313864 Medline TA: Cardiovasc J Afr Country: South Africa |
Other Details:
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Languages: eng Pagination: 25-30 Citation Subset: IM |
Affiliation:
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Department of Medicine, Coronary Care Unit, RK Khan Hospital, Chemical Pathology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, and Biostatistics Unit, Medical Research Council of South Africa. ranjith@lantic.co.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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genetics Adiposity / ethnology Adult Asian Continental Ancestry Group / genetics* Biological Markers / blood Case-Control Studies Chi-Square Distribution Female Gene Frequency Genetic Predisposition to Disease Humans Male Metabolic Syndrome X / blood, ethnology, genetics*, physiopathology Middle Aged Myocardial Infarction / blood, ethnology, genetics*, physiopathology Obesity / blood, ethnology, genetics*, physiopathology Odds Ratio Phenotype Polymorphism, Single Nucleotide* Proteins / genetics Receptor, Melanocortin, Type 4 / genetics Risk Assessment Risk Factors South Africa / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/FTO protein, human; 0/MC4R protein, human; 0/Proteins; 0/Receptor, Melanocortin, Type 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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