Document Detail

Obesity-associated endometrial and cervical cancers.
MedLine Citation:
PMID:  23276974     Owner:  NLM     Status:  In-Data-Review    
Epidemiological studies have indicated that obesity (body mass index-BMI>30) and overweight (BMI>25) directly associated with risk of many cancers. The association of obesity with cancer risks may be explained by the alterations in the metabolism of endogenous hormones, production of specific proteins and cytokines, adipose related inflammatory reactions, and genetic factors. This review aims to illustrate the link between obesity and occurrence and prognosis of endometrial and cervical cancers. Convincing scientific evidence shows that nutrition and lifestyle factors initiate the development of obesity with excessive adipose tissues, which trigger production of hormones, cytokines and other factors to promote growth of cancer cells. Obese women with either endometrial or cervical cancer, especially in postmenopausal period, have shown a significantly higher mortality. This is mainly due to that the obese women are more vulnerable in cancer occurrence and they are more likely to miss routine cancer screening, putting them at a greater risk for delayed diagnosis of these cancers and deteriorate prognosis. Thus, healthcare providers should pay particular attention to this more vulnerable group of women.
Wenyi Gu; Chen Chen; Kong-Nan Zhao
Related Documents :
23102584 - Can we deconstruct cancer, one patient at a time?
24066954 - Micrornas in body fluids as biomarkers for non-small cell lung cancer: a systematic rev...
23215564 - Intermittent androgen suppression for rising psa level.
24324074 - Association of x-ray repair cross-complementing-6 genotypes with childhood leukemia.
18087604 - Management of arthralgias associated with aromatase inhibitor therapy.
21573504 - Mir-185 and mir-133b deregulation is associated with overall survival and metastasis in...
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-18     Citation Subset:  IM    
UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, QLD, 4029, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sphingolipid signaling in yeast: potential implications for understanding disease.
Next Document:  Vascular endothelial cells and dysfunctions: role of melatonin.