| Obesity and age of first non-ST-segment elevation myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 18786477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Because excess adiposity is one of the most important determinants of adipokines and inflammatory factors associated with coronary plaque rupture, we hypothesized that obesity was associated with myocardial infarction at earlier ages. BACKGROUND: The developing obesity pandemic of the past 50 years has gained considerable attention as a major public health threat. METHODS: The CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines) registry was a voluntary observational data collection and quality improvement initiative that began in November 2001, with retrospective data collection from January 2001 to January 2007. The CRUSADE initiative included high-risk patients with unstable angina and non-ST-segment elevation myocardial infarction (NSTEMI). We retrospectively examined, among 189,065 patients with acute coronary syndrome (between January 2001 and September 2006) in the CRUSADE initiative, the relationship of body mass index (BMI) with patient age of first NSTEMI. RESULTS: A total of 111,847 patients with NSTEMI were included in the final analysis. There was a strong, inverse linear relationship between BMI and earlier age of first NSTEMI. The mean patient ages (+/- SD) of first NSTEMI were 74.6 +/- 14.3 years and 58.7 +/- 12.5 years for the leanest (BMI <or=18.5 kg/m(2)) and most obese (BMI >40.0 kg/m(2)) cohorts, respectively (p < 0.0001). After adjustment for baseline demographic data, cardiac risk factors, and medications, the age of first NSTEMI occurred 3.5, 6.8, 9.4, and 12.0 years earlier with ascending levels of adiposity (BMI 25.1 to 30.0, 30.1 to 35.0, 35.1 to 40.0, and >40.0 kg/m(2), respectively; referent 18.6 to 25.0 kg/m(2)) (p < 0.0001 for each estimate). CONCLUSIONS: Excess adiposity is strongly related to first NSTEMI occurring prematurely. |
| | |
Authors:
|
Mohan C Madala; Barry A Franklin; Anita Y Chen; Aaron D Berman; Matthew T Roe; Eric D Peterson; E Magnus Ohman; Sidney C Smith; W Brian Gibler; Peter A McCullough; |
Related Documents
:
|
18296837 - Clinical implications of serial changes in st-segment elevation after reperfusion in pa... 18707987 - Acute myocardial infarction. 15109937 - Spinal cord activation differentially modulates ischaemic electrical responses to diffe... 1985377 - Incidence and clinical significance of st segment elevation after electrical cardiovers... 10543547 - Results of a prospective multicenter study on port-access coronary bypass grafting. 19153497 - Primary aldosteronism. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 52 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-12 Completed Date: 2008-10-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 979-85 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, Division of Cardiology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age of Onset Aged Aged, 80 and over Body Mass Index Female Humans Male Middle Aged Myocardial Infarction / epidemiology*, etiology Obesity / complications, epidemiology* Retrospective Studies Risk Factors United States / epidemiology |
| Comments/Corrections | |
Comment In:
|
J Am Coll Cardiol. 2008 Sep 16;52(12):986-7
[PMID:
18786478
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hemoxygenase-1 in cardiovascular disease.
Next Document: Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwid...