| Obesity, adipose tissue and rheumatoid arthritis: coincidence or more complex relationship? | |
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MedLine Citation:
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PMID: 21640051 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the last two decades we have witnessed a boost in scientific interest and knowledge of adipose tissue biology to such an extent that it was promoted to an active endocrine organ. Adipose tissue is not just related to body weight and appetite regulation. It is also implicated in obesity, a low-grade inflammatory state, as well as inflammatory conditions including rheumatoid arthritis (RA), an autoimmune disease where anti- and pro-inflammatory cytokine balance is critical. All major adipose derived products, simply termed adipokines, like leptin, adiponectin, visfatin and resistin, reportedly participate in inflammation and immunity. In this review we explore in depth the relationship between adipose tissue and RA, with focus on possible mechanisms, beyond observations about circulating or synovial levels, and special reference to future perspectives and clinical implications. |
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Authors:
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Christos S Derdemezis; Paraskevi V Voulgari; Alexandros A Drosos; Dimitrios N Kiortsis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-1 |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: - ISSN: 0392-856X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Physiology, Medical School, University of Ioannina, Greece. kkma5333@yahoo.gr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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