Document Detail

Obesity and addiction: neurobiological overlaps.
MedLine Citation:
PMID:  23016694     Owner:  NLM     Status:  MEDLINE    
Drug addiction and obesity appear to share several properties. Both can be defined as disorders in which the saliency of a specific type of reward (food or drug) becomes exaggerated relative to, and at the expense of others rewards. Both drugs and food have powerful reinforcing effects, which are in part mediated by abrupt dopamine increases in the brain reward centres. The abrupt dopamine increases, in vulnerable individuals, can override the brain's homeostatic control mechanisms. These parallels have generated interest in understanding the shared vulnerabilities between addiction and obesity. Predictably, they also engendered a heated debate. Specifically, brain imaging studies are beginning to uncover common features between these two conditions and delineate some of the overlapping brain circuits whose dysfunctions may underlie the observed deficits. The combined results suggest that both obese and drug-addicted individuals suffer from impairments in dopaminergic pathways that regulate neuronal systems associated not only with reward sensitivity and incentive motivation, but also with conditioning, self-control, stress reactivity and interoceptive awareness. In parallel, studies are also delineating differences between them that centre on the key role that peripheral signals involved with homeostatic control exert on food intake. Here, we focus on the shared neurobiological substrates of obesity and addiction.
N D Volkow; G-J Wang; D Tomasi; R D Baler
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-09-27
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  14     ISSN:  1467-789X     ISO Abbreviation:  Obes Rev     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-02-01     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  2-18     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. obesity reviews © 2012 International Association for the Study of Obesity.
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MeSH Terms
Behavior, Addictive*
Brain / metabolism
Dopamine / metabolism
Eating / physiology,  psychology
Models, Biological
Neural Pathways
Obesity / epidemiology*,  metabolism*,  psychology
Substance-Related Disorders / epidemiology*,  metabolism,  psychology
Reg. No./Substance:
Comment In:
Obes Rev. 2013 Jan;14(1):19-28   [PMID:  23057499 ]

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