Document Detail


Obesity and right ventricular structure and function: the MESA-Right Ventricle Study.
MedLine Citation:
PMID:  21868467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The relationship between obesity and right ventricular (RV) morphology is not well studied. We aimed to determine the association between obesity and RV structure and function in a large multiethnic population-based cohort.
METHODS: The MESA-Right Ventricle Study measured RV mass and volumes by cardiac MRI in participants aged 45 to 84 years without clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis (MESA). Participants were divided into three categories based on BMI: lean ( ≤ 24.9 kg/m(2)), overweight (25-29.9 kg/m(2)), and obese ( ≥ 30 kg/m(2)).
RESULTS: The study sample included 4,127 participants. After adjustment for demographics, height, education, and cardiovascular risk factors, overweight and obese participants had greater RV mass (6% and 9% greater, respectively), larger RV end-diastolic volume (8% and 18% greater, respectively), larger RV stroke volume (7% and 16% greater, respectively), and lower RV ejection fraction ( ≥ 1% lower) than lean participants (all P < .001). These findings persisted after adjusting for the respective left ventricular (LV) parameters.
CONCLUSIONS: Overweight and obesity were independently associated with differences in RV morphology even after adjustment for the respective LV measure. This association could be explained by increased RV afterload, increased blood volume, hormonal effects, or direct obesity-related myocardial effects.
Authors:
Harjit Chahal; Robyn L McClelland; Harikrishna Tandri; Aditya Jain; Evrim B Turkbey; W Gregory Hundley; R Graham Barr; Jorge Kizer; João A C Lima; David A Bluemke; Steven M Kawut
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2011-08-25
Journal Detail:
Title:  Chest     Volume:  141     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-08     Completed Date:  2012-04-03     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  388-95     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Body Mass Index
Female
Heart Ventricles / physiopathology*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Obesity / ethnology,  physiopathology*
Prospective Studies
Grant Support
ID/Acronym/Agency:
N01-HC95159/HC/NHLBI NIH HHS; N01-HC95160/HC/NHLBI NIH HHS; N01-HC95161/HC/NHLBI NIH HHS; N01-HC95162/HC/NHLBI NIH HHS; N01-HC95163/HC/NHLBI NIH HHS; N01-HC95164/HC/NHLBI NIH HHS; N01-HC95165/HC/NHLBI NIH HHS; N01-HC95166/HC/NHLBI NIH HHS; N01-HC95167/HC/NHLBI NIH HHS; N01-HC95168/HC/NHLBI NIH HHS; N01-HC95169/HC/NHLBI NIH HHS; R01 HL077612/HL/NHLBI NIH HHS; R01-HL077612/HL/NHLBI NIH HHS; R01-HL086719/HL/NHLBI NIH HHS
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