| Obesity, Insulin resistance and Alzheimer's Disease. | |
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MedLine Citation:
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PMID: 22310232 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is well known that age-related increases in obesity and insulin resistance (IR) greatly increase the risk of type 2 diabetes and cardiovascular disease. However, we are just beginning to appreciate the role of obesity and IR in cognitive decline and dementia. Research increasingly supports a multifaceted role for insulin in the central nervous system, including involvement in learning and memory. A growing body of work suggests that insulin is also important for normal cognitive function, and that abnormalities in insulin sensitivity may promote or exacerbate cognitive impairment. The number of individuals with cognitive impairment is expected to increase exponentially as the population ages, exacting an enormous toll on patients, caregivers, and an already strained health-care system. Given the high and growing prevalence of obesity, even a modest association with cognitive impairment could significantly worsen this alarming trend. In addition, the rising rate of obesity in younger populations raises the possibility of cognitive impairment beginning at earlier ages, further compounding these problems. Identification and treatment of modifiable risk factors, such as obesity and IR, that could prevent or delay clinical dementia and functional impairment may have a significant impact on disease prevalence, associated morbidity, and costs of care. We review here the role that hyperinsulinemia and IR (both central and peripheral) may play in the development and progression of cognitive impairment, with particular emphasis on AD. We also address the limited available literature on pharmacologic and non-pharmacologic interventions that target IR with respect to their effects on cognitive function. |
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Authors:
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K L Hildreth; R E Van Pelt; R S Schwartz |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-07 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: - ISSN: 1930-7381 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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