| Obesity hypoventilation syndrome: mechanisms and management. | |
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MedLine Citation:
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PMID: 21037018 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Obesity hypoventilation syndrome describes the association between obesity and the development of chronic daytime alveolar hypoventilation. This syndrome arises from a complex interaction between sleep-disordered breathing, diminished respiratory drive, and obesity-related respiratory impairment, and is associated with significant morbidity and mortality. Therapy directed toward reversing these abnormalities leads to improved daytime breathing, with available treatment options including positive pressure therapy, weight loss, and pharmacological management. However, a lack of large-scale, well-designed studies evaluating these various therapies has limited the development of evidence-based treatment recommendations. Although treatment directed toward improving sleep-disordered breathing is usually effective, not all patients tolerate mask ventilation and awake hypercapnia may persist despite effective use. In the longer term, weight loss is desirable, but data on the success and sustainability of this approach in obesity hypoventilation are lacking. The review outlines the major mechanisms believed to underlie the development of hypoventilation in this subgroup of obese patients, their clinical presentation, and current therapy options. |
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Authors:
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Amanda J Piper; Ronald R Grunstein |
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Publication Detail:
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Type: Journal Article Date: 2010-10-29 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 183 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 292-8 Citation Subset: AIM; IM |
Affiliation:
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Sleep Unit, Level 11, Building 75, Royal Prince, Alfred Hospital, Missenden Road, Camperdown, NSW 2050 Australia. ajp@med.usyd.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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