Document Detail


Obese and lean Zucker rats demonstrate differential sensitivity to rates of food reinforcement in a choice procedure.
MedLine Citation:
PMID:  23046726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The obese Zucker rat carries two recessive fa alleles that result in the expression of an obese phenotype. Obese Zuckers have higher food intake than lean controls in free-feed studies in which rats have ready access to a large amount of one type of food. The present study examined differences in obese and lean Zucker rats using concurrent schedules of reinforcement, which more ecologically models food selection using two food choices that have limited, but generally predictable availability. Lever-pressing of ten lean (Fa/Fa or Fa/fa) and ten obese (fa/fa) Zucker rats was placed under three concurrent variable interval variable interval (conc VI VI) schedules of sucrose and carrot reinforcement, in which the programmed reinforcer ratios for 45-mg food pellets were 5:1, 1:1, and 1:5. Allocation of responses to the two food alternatives was characterized using the generalized matching equation, which allows sensitivity to reinforcer rates (a) and bias toward one alternative (log k) to be quantified. All rats showed a bias toward sucrose, though there were no differences between lean and obese Zucker rats. In addition, obese Zucker rats exhibited higher sensitivity to reinforcement rates than lean rats. This efficient pattern of responding was related to overall higher deliveries of food pellets. Effective matching for food, then, may be another behavioral pattern that contributes to an obese phenotype.
Authors:
Jessica L Buckley; Erin B Rasmussen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-06
Journal Detail:
Title:  Physiology & behavior     Volume:  108     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-10     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Choice Behavior / physiology*
Conditioning, Operant / physiology*
Eating
Food Preferences / psychology*
Linear Models
Male
Obesity / genetics,  physiopathology*
Rats
Rats, Zucker
Reinforcement (Psychology)*
Reinforcement Schedule
Sucrose / administration & dosage
Sweetening Agents / administration & dosage
Grant Support
ID/Acronym/Agency:
P20 GM103408/GM/NIGMS NIH HHS; P20 GM103408/GM/NIGMS NIH HHS; P20 RR016454/RR/NCRR NIH HHS; P20 RR016454/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Sweetening Agents; 57-50-1/Sucrose
Comments/Corrections

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