Document Detail

The OSCAR for cardiovascular disease prevention in chronic kidney disease goes to blood pressure control.
MedLine Citation:
PMID:  23271487     Owner:  NLM     Status:  MEDLINE    
Nephropathy progression is slowed and cardiovascular events reduced in patients with stage 3 or higher chronic kidney disease when blood pressure is controlled using combinations of renin-angiotensin system (RAS) blockers with dihydropyridine calcium channel blockers or diuretics. We discuss a trial comparing high-dose RAS blockade with lower-dose RAS blockade combined with a dihydropyridine calcium channel blocker. The primary outcome was cardiovascular events. The combination group had better blood pressure control and fewer total events.
Alexandros Briasoulis; George L Bakris
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  83     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-28     Completed Date:  2013-06-17     Revised Date:  2013-08-22    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-2     Citation Subset:  IM    
American Society of Hypertension, Comprehensive Hypertension Center, Department of Medicine, University of Chicago Medicine, Chicago, IL 60637, USA.
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MeSH Terms
Angiotensin Receptor Antagonists / therapeutic use*
Calcium Channel Blockers / therapeutic use*
Cardiovascular Diseases / prevention & control*
Hypertension / complications*,  epidemiology*
Renal Insufficiency, Chronic / complications*,  epidemiology*
Reg. No./Substance:
0/Angiotensin Receptor Antagonists; 0/Calcium Channel Blockers
Comment On:
Kidney Int. 2013 Jan;83(1):167-76   [PMID:  23051740 ]
Comment In:
Kidney Int. 2013 Jul;84(1):214-5   [PMID:  23812366 ]
Kidney Int. 2013 Jul;84(1):215   [PMID:  23812368 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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