Document Detail


ORF 13904, a new long-acting vaginal contraceptive.
MedLine Citation:
PMID:  3002719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A sulfonated polystyrene polymer, ORF 13904, was discovered in our laboratory to be a highly effective vaginal contraceptive in the rabbit model and to possess a unique mode of action. It was found to be non-spermicidal even at high concentrations, yet it greatly impeded sperm penetration of cervical mucus in vitro. When a gel formulation containing 5% ORF 13904 was administered to rabbits intravaginally, the mean number of fetal implants was reduced dramatically even when coitus was delayed for up to 8 hours or when multiple matings at different time intervals were permitted. The non-spermicidal qualities and extended duration of action of this compound represent major breakthroughs in the development of vaginal contraceptives.
Authors:
R E Homm; R G Foldesy; D W Hahn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contraception     Volume:  32     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-03-12     Completed Date:  1986-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Cervix Mucus
Contraceptive Agents, Female* / administration & dosage
Female
Humans
Male
Nonoxynol
Polyethylene Glycols / administration & dosage,  pharmacology
Polystyrenes / administration & dosage*,  pharmacology
Pregnancy
Rabbits
Sperm Motility / drug effects
Sperm Transport / drug effects
Time Factors
Vagina
Chemical
Reg. No./Substance:
0/Contraceptive Agents, Female; 0/Polyethylene Glycols; 0/Polystyrenes; 100179-04-2/ORF 13904; 26027-38-3/Nonoxynol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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