| OPG, RANK-L, bone metabolism, and BMD in patients on peritoneal dialysis and hemodialysis. | |
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MedLine Citation:
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PMID: 16530745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Bone turnover is regulated locally by osteoprotegerin (OPG) and receptor activator of NFkappaB ligand (RANK-L); it is not known how the circulating concentrations of these cytokines reflect renal osteodystrophy. METHODS: We measured serum OPG, RANK-L, parathyroid hormone (iPTH), collagen C-terminal cross-linked telopeptide (betaCrossLaps), and bone densitometry (BMD) in 79 patients with end-stage renal disease (ESRF) undergoing dialysis. A hand X-ray of these patients was also analyzed. Controls were 65 healthy subjects. RESULTS: ESRF patients had high OPG and RANK-L levels; RANK-L was higher in hemodialysis than in peritoneal dialysis. OPG and RANK-L did not depend on iPTH. The bone markers were significantly increased and correlated with serum iPTH, but not with OPG or RANK-L; neither OPG nor RANK-L correlated significantly with BMD. OPG was significantly higher in patients with acro-osteolysis. CONCLUSIONS: OPG and RANK-L serum concentrations do not strongly reflect bone status in ESRF. However, OPG was significantly higher in patients with acro-osteolysis. |
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Authors:
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Eric Wittersheim; Maria Mesquita; Anne Demulder; Martine Guns; Olivia Louis; Christian Melot; Max Dratwa; Pierre Bergmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-10 |
Journal Detail:
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Title: Clinical biochemistry Volume: 39 ISSN: 0009-9120 ISO Abbreviation: Clin. Biochem. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-23 Completed Date: 2006-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 617-22 Citation Subset: IM |
Affiliation:
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Laboratory of Haematology, CHU Brugmann, Place Van Gehuchten, 4, 1020 Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Bone Density* Bone Remodeling Bone and Bones / metabolism* Carrier Proteins / metabolism* Female Glycoproteins / metabolism* Hand / radiography Humans Kidney Failure, Chronic / metabolism, therapy* Male Membrane Glycoproteins / metabolism* Middle Aged Osteoprotegerin Peritoneal Dialysis* RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear / metabolism* Receptors, Tumor Necrosis Factor / metabolism* Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Glycoproteins; 0/Membrane Glycoproteins; 0/Osteoprotegerin; 0/RANK Ligand; 0/Receptor Activator of Nuclear Factor-kappa B; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF11A protein, human; 0/TNFRSF11B protein, human; 0/TNFSF11 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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