Document Detail


ONCOPOOL - a European database for 16,944 cases of breast cancer.
MedLine Citation:
PMID:  19811907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DATA: Data were date of birth, mode of diagnosis, pathology (size, lymph node status, grade, type, lympho-vascular invasion and hormone receptor) and therapies and outcome measures: first local, regional or distant recurrences, contralateral primary, date and cause of death.
TUMOUR CHARACTERISTICS: Mean diameter 1.8 cm, 66% lymph node negative, 24% 1-3 lymph nodes involved and 10% had 4 or more involved. Grade 1, 29%; Grade 2, 41%; and Grade 3, 30%. Polynomial relationships were established between grade, stage and size. Seventy-five percent were oestrogen receptor (ER) positive. ER closely related to grade.
OUTCOMES: Overall Survival was 89% at 5 years from diagnosis, 80% 10 years and 73% 15 years; Breast Cancer-Specific survivals were 91%, 84% and 79%. Survival strongly related to the Nottingham Prognostic Index (NPI). Cases detected at screening had 84% 10-year survival, those presenting symptomatically 76%. ER positive cases treated with adjuvant hormone therapy had a reduction in risk of death of 13% over those not receiving adjuvant therapy (p=0.000). ER negative cases treated with chemotherapy showed a risk reduction of 23% over those not receiving chemotherapy (p=0.000).
Authors:
R W Blamey; B Hornmark-Stenstam; G Ball; M Blichert-Toft; L Cataliotti; A Fourquet; J Gee; K Holli; R Jakesz; M Kerin; R Mansel; R Nicholson; T Pienkowski; S Pinder; M Sundquist; M van de Vijver; I Ellis
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  46     ISSN:  1879-0852     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-25     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  56-71     Citation Subset:  IM    
Affiliation:
ONCOPOOL Consortium at Breast Institute, Nottingham City Hospital, NG5 1PB, UK. rogerblamey@btinternet.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Age Factors
Aged
Breast Neoplasms / diagnosis,  epidemiology*,  pathology,  therapy
Chemotherapy, Adjuvant
Databases, Factual*
Europe / epidemiology
Female
Humans
Lymphatic Metastasis
Middle Aged
Neoplasm Proteins / metabolism
Neoplasm Staging
Prognosis
Quality Assurance, Health Care
Receptors, Estrogen / metabolism
Receptors, Progesterone / metabolism
Survival Analysis
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/Receptors, Estrogen; 0/Receptors, Progesterone
Comments/Corrections
Erratum In:
Eur J Cancer. 2010 Jun;46(9):1762

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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