| OMICS in assisted reproduction: possibilities and pitfalls. | |
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MedLine Citation:
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PMID: 20538894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A key step in assisted reproduction is the assessment of oocyte and embryo developmental potential in order to determine the embryo(s) most likely to result in pregnancy. Currently used embryo assessment strategies are largely based on embryo morphology and cleavage rate. Although these systems have been successful in improving pregnancy rates and reducing multiple gestations, their precision is still insufficient. Therefore, development of an objective, accurate, fast and affordable test that can aid in the assessment of oocyte and embryo developmental potential is a significant aim of reproductive medicine. Recently, global assessment strategies involving genomic, transcriptomic, proteomic or metabolomic profiling of oocytes, granulosa or cumulus cells, embryos or culture media have been applied to assisted reproduction. These technologies are at different stages of development and present unique advantages as well as limitations. |
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Authors:
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Emre Seli; Claude Robert; Marc-Andre Sirard |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-06-10 |
Journal Detail:
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Title: Molecular human reproduction Volume: 16 ISSN: 1460-2407 ISO Abbreviation: Mol. Hum. Reprod. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513710 Medline TA: Mol Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 513-30 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Genetic Predisposition to Disease Humans In Situ Hybridization, Fluorescence Male Microarray Analysis Pregnancy Reproductive Techniques, Assisted* / trends |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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