Document Detail


OIT3 deficiency impairs uric acid reabsorption in renal tubule.
MedLine Citation:
PMID:  22306318     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The oncoprotein induced transcript 3 (OIT3), also named liver-specific zona pellucida domain-containing protein (LZP), has been shown to be expressed in kidney, and was confirmed to interact with the Tamm-Horsfall glycoprotein (THP). However, the function of OIT3 in kidney remains unclear. In this study we found that serum uric acid level of Oit3 null mice was significantly lower than that in wild type controls, whereas the excretion of uric acid in urine increased in the mutant mouse. Significantly, the excretion of THP in urine also increased while renal THP decreased in Oit3 null mice. Our data suggest that OIT3 could maintain urate homeostasis by regulating the excretion and reabsorption of uric acid in renal tubule via cooperating with THP.
Authors:
Bing Yan; Zhuang-Zhuang Zhang; Li-Yu Huang; Hai-Lian Shen; Ze-Guang Han
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-28
Journal Detail:
Title:  FEBS letters     Volume:  -     ISSN:  1873-3468     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
National Human Genome Center of Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui-Jin II Road, Shanghai 200025, China; Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou-Jing Road, Shanghai 201203, China.
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