Document Detail


OEIS complex--a population study.
MedLine Citation:
PMID:  10797425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using a novel method for the analysis of infants with multiple malformations, we investigated the cluster of associated malformations called the OEIS (omphalocele, bladder exstrophy, imperforate anus, spine defect) complex among 5,260 infants with multiple malformations identified in four large registers of congenital malformations, corresponding to 5.84 million births. The existence of the OEIS complex was clearly demonstrated and malformations entering it could be defined. Other than the four classical malformations, omphalocele, bladder exstrophy, imperforate anus, and spine malformation, a strong association with spina bifida and intersex was stressed. Spine malformations occurred not only in the lumbosacral level but also more cranially, and an association also with upper spina bifida could be demonstrated. No specific association with any other malformation, including cardiac defects, was apparent. The OEIS complex is an unusually clearly defined entity among the various nonrandom associations which have been described.
Authors:
K Källén; E E Castilla; E Robert; P Mastroiacovo; B Källén
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics     Volume:  92     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-24     Completed Date:  2000-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Affiliation:
Tornblad Institute, University of Lund, Lund, Sweden. Karin.Kallen@anatom.lu.se
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / classification,  epidemiology*
Anus, Imperforate*
Bladder Exstrophy*
Cohort Studies
Epidemiologic Methods
France / epidemiology
Hernia, Umbilical*
Humans
Infant, Newborn
Italy / epidemiology
South America / epidemiology
Spinal Dysraphism*
Sweden / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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