Document Detail

OC125 immunoscintigraphy in ovarian carcinoma: a comparison with alternative methods of assessment.
MedLine Citation:
PMID:  2261415     Owner:  NLM     Status:  MEDLINE    
The membrane bound, tumour associated antigen CA125 is recognized by the monoclonal antibody OC125 and may be detected in tumour tissue and serum in over 80% of patients with epithelial ovarian carcinomas. A total of 13 immunoscintigrams using 111 MBq 131I-OC125 have been performed in 11 patients. The results have been compared with clinical examination, CT and ultrasound scans, surgical findings and serum CA125 concentrations. Macroscopic disease was present at the time of scanning in 11 patients (less than 2 cm, eight patients, greater than 2 cm, three patients). Clinical examination and ultrasound were positive in three, CT scanning in four, immunoscintography in seven and serum CA125 in eight patients. This pilot study suggest that serum CA125 estimation is the most sensitive indicator of disease activity. However, immunoscintigraphy using this agent may localize residual disease when clinical examination and other radiological investigations fail.
T S Maughan; B Haylock; M Hayward; P Facey; W D Evans; M D Shelley; R G Fish; M Adams
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical oncology (Royal College of Radiologists (Great Britain))     Volume:  2     ISSN:  0936-6555     ISO Abbreviation:  Clin Oncol (R Coll Radiol)     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1991-02-07     Completed Date:  1991-02-07     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9002902     Medline TA:  Clin Oncol (R Coll Radiol)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  199-205     Citation Subset:  IM    
South Wales Radiotherapy and Oncology Service, Velindre Hospital, Cardiff, UK.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use*
Antigens, Tumor-Associated, Carbohydrate / immunology*
Iodine Radioisotopes / diagnostic use*
Neoplasm Recurrence, Local / radionuclide imaging
Ovarian Neoplasms / diagnosis,  pathology,  radionuclide imaging*
Pelvic Neoplasms / radionuclide imaging,  secondary
Pilot Projects
Sensitivity and Specificity
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Tumor-Associated, Carbohydrate; 0/Iodine Radioisotopes

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