Document Detail

O2 pressures between 0.12 and 2.5 atm abs, circulatory function, and N2 elimination.
MedLine Citation:
PMID:  1887516     Owner:  NLM     Status:  MEDLINE    
To study the effects of inhaled oxygen pressures on N2 elimination, 72, 2-h washouts were performed in 6 subjects at oxygen pressures of 0.12, 0.2, 1.0, 2.0, and 2.5 atm abs using a closed circuit system that supplied an O2-argon mixture and collected the N2 off-gassed. Hypoxia induced a significant (9.4%, P less than 0.05) increase in nitrogen eliminated as compared to normoxia. Pure oxygen breathing induced a small, insignificant (3.5%) decrease in nitrogen yields, but further increases in oxygen pressure induced significant decreases in nitrogen yields (-8.9% and -16.9% for 2.0 and 2.5 atm abs, respectively). Heart rate, cardiac output, skin perfusion and leg blood flow decreased, whereas mean arterial pressure increased with increasing oxygen pressure. We conclude, therefore, that perfusion-dependent N2 elimination decreases secondary to vasoconstriction induced by increasing oxygen pressures. Changes in inhaled oxygen pressures during different phases of compression-decompression may induce alterations in the rate of inert gas uptake and elimination. Although not currently quantifiable, such alterations would imply added uncertainties in the computation of decompression schedules. Oxygen breathing during decompression should be performed at the lowest possible ambient pressure compatible with freedom from pathogenic bubble formation.
D Anderson; G Nagasawa; W Norfleet; A Olszowka; C Lundgren
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Undersea biomedical research     Volume:  18     ISSN:  0093-5387     ISO Abbreviation:  Undersea Biomed Res     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-10-09     Completed Date:  1991-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421514     Medline TA:  Undersea Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-92     Citation Subset:  IM; S    
Hermann Rahn Laboratory of Environmental Physiology, State University of New York, Department of Physiology, School of Medicine, Buffalo 14214.
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MeSH Terms
Atmospheric Pressure
Blood Pressure
Cardiac Output / physiology*
Heart Rate / physiology*
Nitrogen / metabolism*
Oxygen / administration & dosage*
Partial Pressure
Skin / blood supply
Reg. No./Substance:
7727-37-9/Nitrogen; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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