Document Detail


O-GlcNAc Modification Prevents Peptide-Dependent Acceleration of α-Synuclein Aggregation.
MedLine Citation:
PMID:  23143740     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Sweet relief: The Parkinson's disease-associated protein α-synuclein is post-translationally modified by N-acetylglucosamine (O-GlcNAc), but the biochemical consequences are unknown. Here we show that an O-GlcNAc-modified peptide does not participate in α-synuclein aggregation, thus suggesting that O-GlcNAc might directly inhibit aggregation in cells.
Authors:
Nicholas P Marotta; Carli A Cherwien; Tharindumala Abeywardana; Matthew R Pratt
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  -     ISSN:  1439-7633     ISO Abbreviation:  Chembiochem     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Departments of Chemistry and Molecular and Computational Biology, University of Southern California, 840 Downey Way, LJS 250, Los Angeles, CA 90089-0744 (USA).
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