Document Detail


O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence.
MedLine Citation:
PMID:  20334627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.
Authors:
Shannon Weiman; Satoshi Uchiyama; Feng-Ying C Lin; Donald Chaffin; Ajit Varki; Victor Nizet; Amanda L Lewis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-05-13
Journal Detail:
Title:  The Biochemical journal     Volume:  428     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-13     Completed Date:  2010-05-25     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Glycobiology Research and Training Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093-0687, U.S.A.
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Animals
Humans
Kinetics
Male
Mice
N-Acetylneuraminic Acid / genetics,  metabolism*
Neutrophils / immunology*,  metabolism
Polysaccharides, Bacterial / genetics,  immunology,  metabolism
Streptococcus agalactiae / genetics,  immunology*,  metabolism,  pathogenicity*
Virulence / genetics,  physiology*
Grant Support
ID/Acronym/Agency:
P01-HL057345/HL/NHLBI NIH HHS; R01-HD051796/HD/NICHD NIH HHS; Z99 HD999999/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Polysaccharides, Bacterial; 131-48-6/N-Acetylneuraminic Acid
Comments/Corrections

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