| O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence. | |
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MedLine Citation:
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PMID: 20334627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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GBS (Group B Streptococcus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence. |
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Authors:
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Shannon Weiman; Satoshi Uchiyama; Feng-Ying C Lin; Donald Chaffin; Ajit Varki; Victor Nizet; Amanda L Lewis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-13 |
Journal Detail:
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Title: The Biochemical journal Volume: 428 ISSN: 1470-8728 ISO Abbreviation: Biochem. J. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-05-25 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: England |
Other Details:
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Languages: eng Pagination: 163-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Glycobiology Research and Training Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093-0687, U.S.A. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation Animals Humans Kinetics Male Mice N-Acetylneuraminic Acid / genetics, metabolism* Neutrophils / immunology*, metabolism Polysaccharides, Bacterial / genetics, immunology, metabolism Streptococcus agalactiae / genetics, immunology*, metabolism, pathogenicity* Virulence / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P01-HL057345/HL/NHLBI NIH HHS; R01-HD051796/HD/NICHD NIH HHS; Z99 HD999999/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Polysaccharides, Bacterial; 131-48-6/N-Acetylneuraminic Acid |
| Comments/Corrections | |
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