Document Detail

Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levels.
MedLine Citation:
PMID:  3558729     Owner:  NLM     Status:  MEDLINE    
The effects of aging on GH secretion and somatomedin-C (SM-C) levels were studied in 10 young (22-45 yr) and 10 elderly (65-85 yr) men. Plasma GH levels were measured in samples obtained at 20-min intervals for 1300 min. Plasma SM-C levels were measured in samples obtained at 0600, 1100, 1600, 2100, and 0200 h. In the elderly men the mean basal plasma GH level was similar to that in the young men, but the total GH peak area as well as the amplitude of the peaks were significantly (p less than 0.01) lower than those in young men during both the day and the night. Plasma SM-C levels were significantly lower in the elderly men and were correlated with the total integrated GH levels and total GH peak areas, but not with basal plasma GH levels, suggesting that the GH peaks determine SM-C levels and that the decreased GH secretion in elderly men has biological significance.
A Vermeulen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  64     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  884-8     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Aging / physiology*
Circadian Rhythm*
Growth Hormone / blood*
Insulin-Like Growth Factor I / blood*
Middle Aged
Somatomedins / blood*
Reg. No./Substance:
0/Somatomedins; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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