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Nutritional vitamin D supplementation in hemodialysis: a potential vascular benefit?
MedLine Citation:
PMID:  22181351     Owner:  NLM     Status:  Publisher    
Aim  Vitamin D deficiency is highly prevalent in end-stage renal disease and has been associated with atherosclerosis, endothelial dysfunction and left ventricular hypertrophy. Although activated vitamin D has shown to be cardioprotective, the cardiovascular benefits of nutritional vitamin D (i.e. ergocalciferol or cholecalciferol) has not been explored in the dialysis population. The aim of this investigation was to evaluate the effect of ergocalciferol therapy on vascular adhesion molecules, markers of inflammation and atherosclerosis among hemodialysis patients. Methods  This was a pilot study of matched hemodialysis patients. For every patient enrolled taking ergocalciferol, an age and race matched control was recruited. Pre-dialysis blood samples were collected and assayed for adhesion molecules (sVCAM-1, sICAM-1, E-selectin and P-selectin), inflammatory cytokines (IL-6 and TNF-α), oxLDL-β(2) GPI and IgG anticardiolipin. Results  A total of 40 hemodialysis patients were studied (20 on ergocalciferol therapy, 20 not receiving ergocalciferol therapy). Patients taking ergocalciferol had higher 25-hydroxyvitamin D levels compared to those not taking ergocalciferol. Even though doxercalciferol usage and dosing was similar between groups, plasma s-VCAM-1, sICAM-1 and P-selectin concentrations were lower among ergocalciferol treated patients. No significant differences in E-selectin, IL-6 , TNF-α, oxLDL-β(2) GPI or anticardiolipin antibody levels were observed. Conclusions  Patients receiving ergocalciferol had lower plasma levels of vascular adhesion molecules despite equivalent use of activated vitamin D therapy. Future investigations should confirm the role of nutritional vitamin D therapy, in addition to activated D therapy, in hemodialysis patients and the potential vascular benefits of these agents.
Magdalene M Assimon; Page V Salenger; Hassan A N El-Fawal; Darius L Mason
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-19
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Nephrology © 2011 Asian Pacific Society of Nephrology.
Albany College of Pharmacy and Health Sciences 106 New Scotland Ave. Albany, NY 12208 The Hortenese & Louis Rubin Dialysis Center, Inc. 21 Crossings Blvd., Suite B Clifton Park, NY 12065.
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