| Nutritional up-regulation of serotonin paradoxically induces compulsive behavior. | |
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MedLine Citation:
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PMID: 21040623 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Dietary etiologies or treatments for complex mental disorder are highly controversial in psychiatry. Nevertheless, diet affects brain chemistry (particularly serotonin), and can reduce abnormal behavior in humans and animals. We formulated a diet that elevated brain serotonin and tested whether it would reduce hair pulling in a mouse model of trichotillomania. In a double-blind crossover trial, dietary elevation of brain serotonin unexpectedly increased hair pulling (P = 0.0006) and induced ulcerative dermatitis (UD; P = 0.001). The causative agent for UD is unknown. Therefore, we fed the treatment diet to a second group of mice to test whether UD is behavioral in origin. The diet increased scratching behavior (P < 0.0001). However, high scratching behavior (P = 0.027) and low barbering (P = 0.040) prior to treatment predicted the development of UD. Thus diet can trigger the onset of a complex disorder in the absence of an underlying metabolic deficit. Furthermore, we propose UD as model of compulsive skin-picking. |
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Authors:
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Brett D Dufour; Olayiwola Adeola; Heng-Wei Cheng; Shawn S Donkin; Jon D Klein; Edmond A Pajor; Joseph P Garner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutritional neuroscience Volume: 13 ISSN: 1476-8305 ISO Abbreviation: Nutr Neurosci Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 256-64 Citation Subset: IM |
Affiliation:
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Department of Animal Sciences, Purdue University, West Lafayette, Indiana 47907, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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