| Nutritional toxicology: on the mechanisms of inhibition of formation of potent carcinogens during cooking. | |
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MedLine Citation:
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PMID: 2675035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Frying or broiling of meat or fish yields powerful genotoxic carcinogens such as 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and related amino-imidazo azaarene carcinogens. We have explored the mode of formation and inhibition of production of these carcinogens. Maillard reactions from precursor amino acids, hydroxyamino acids, and simple carbohydrates appear to yield reactive aldehydes that interact with creatinine to produce specific mutagens/carcinogens. The simplest such IQ-like mutagen, 2-amino-5-ethylidene-1-methylimidazol-4-one, was prepared from acetaldehyde and creatinine. The formation of mutagens in laboratory models and during realistic frying of meat was effectively blocked by L-tryptophan, L-proline, and mixtures thereof. The underlying mechanism rests on competition, between the inhibitors containing an indole ring and creatinine, for intermediary reactive aldehydes produced during Maillard type reactions. The inhibition by L-tryptophan, L-proline, and other indoles is effective and can also be implemented practically. |
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Authors:
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J H Weisburger; R C Jones |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Progress in clinical and biological research Volume: 304 ISSN: 0361-7742 ISO Abbreviation: Prog. Clin. Biol. Res. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-10-19 Completed Date: 1989-10-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7605701 Medline TA: Prog Clin Biol Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 377-90 Citation Subset: IM |
Affiliation:
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American Health Foundation, Valhalla, New York 10595. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinogens
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chemical synthesis* Cookery* Dietary Fats / adverse effects Food Habits Hot Temperature Humans Mutagens / chemical synthesis, isolation & purification Tryptophan |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Dietary Fats; 0/Mutagens; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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