Document Detail

Nutritional therapy for patients undergoing hemodialysis.
MedLine Citation:
PMID:  17369714     Owner:  NLM     Status:  MEDLINE    
Protein energy malnutrition (PEM) frequently appears in hemodialysis (HD) patients, and it has been established as a risk factor for morbidity and mortality. Recent studies have shown that inflammation might be a key mediator between PEM and cardiovascular events. On the other hand, it remains unknown whether over-nutrition has an implication as a risk factor for cardiovascular diseases and mortality. Although many studies have indicated that obesity seemed not to be directly associated with mortality, metabolic abnormalities including hypertriglyceridemia, a low level of high-density lipoprotein cholesterol, glucose intolerance and visceral fat accumulation are common in HD patients with over-nutrition. Furthermore, the plasma adiponectin concentration has been reported to show an inverse correlation with the visceral fat mass, and low plasma adiponectin was associated with a high susceptibility to cardiovascular events and mortality in HD patients. These results suggest that nutritional therapy for HD patients may be necessary to consider in patients with either PEM or over-nutrition.
Hiromichi Kumagai
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Contributions to nephrology     Volume:  155     ISSN:  0302-5144     ISO Abbreviation:  Contrib Nephrol     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-19     Completed Date:  2007-05-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  59-71     Citation Subset:  IM    
Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
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MeSH Terms
Adiponectin / blood
Cardiovascular Diseases / etiology
Diet Therapy / methods*
Kidney Diseases / complications,  diet therapy*,  therapy*
Metabolic Syndrome X / etiology
Obesity / complications
Protein-Energy Malnutrition / etiology,  prevention & control
Renal Dialysis* / adverse effects
Risk Factors
Reg. No./Substance:

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