Document Detail

Nutritional teratogens: a survey of epidemiological literature.
MedLine Citation:
PMID:  3983169     Owner:  NLM     Status:  MEDLINE    
Alcohol seems to be, by far, the most important nutritional teratogen. Assuming an incidence rate of 1.3%o, 240 newborns with fetal alcohol syndrome per year would be expected in the Netherlands alone. Only a minor fraction of this number is diagnosed as such. Even moderate drinking during pregnancy results in developmental disturbances. There is no safe consumption level. Therefore the intake of alcohol during pregnancy should be abandoned completely. There is conflicting evidence on the effects of caffeine with regard to pregnancy outcome. A slight decrease in birthweight among the offspring of women drinking at least 4 cups of coffee per day seems to be the most consistent finding. In view of the many uncertainties on this subject the intake of caffeine-containing foods and drugs should be curtailed as far as possible. There is a lot of circumstantial evidence in favour of the assumption that high-risk mothers do benefit from vitamin supplementation in the periconceptional period. More research however is needed to elucidate the role of vitamins and other nutrients before supplementation can be recommended in practice as a prophylactic measure.
J J Pieters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  163B     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1985  
Date Detail:
Created Date:  1985-05-23     Completed Date:  1985-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  419-29     Citation Subset:  IM    
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MeSH Terms
Caffeine / adverse effects*
Coffee / adverse effects
Congenital Abnormalities / etiology*
Deficiency Diseases / complications
Ethanol / adverse effects*
Fetal Alcohol Syndrome / etiology*
Infant, Newborn
Plant Diseases
Pregnancy Complications*
Vegetables / adverse effects
Water Supply
Reg. No./Substance:
0/Coffee; 58-08-2/Caffeine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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