Document Detail

Nutritional support for extremely low-birth weight infants: abandoning catabolism in the neonatal intensive care unit.
MedLine Citation:
PMID:  20216411     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Obviously, the ultimate goal in neonatology is to achieve a functional outcome in premature infants that is comparable to healthy term-born infants. As nutrition is one of the key factors for normal cell growth, providing the right amount and quality of nutrients could prove pivotal for normal development. However, many premature infants are catabolic during the first week of life, which has directly been linked to growth failure, disease, and suboptimal long-term outcome. This review describes the progress in research on parenteral nutrition for premature infants with a focus on amino acids and the influence of nutrition on later outcome. RECENT FINDINGS: Although randomized clinical trials on early nutrition for premature infants remain relatively sparse, evidence is accumulating on its beneficial effects both on the short-term and long-term. However, some research also warns for adverse effects. SUMMARY: Despite the fact that substantially improved nutritional therapies for preterm neonates have been implemented, still, some reluctance exists when it comes to providing high amounts of nutrition to the most immature infants. Pros and cons are outlined, as well as deficits in knowledge, when it comes to providing the optimal nutrient strategy in the first postnatal phase.
Chris H P van den Akker; Hester Vlaardingerbroek; Johannes B van Goudoever
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  13     ISSN:  1535-3885     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  327-35     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
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MeSH Terms
Amino Acids / administration & dosage*
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature / metabolism*
Infant, Very Low Birth Weight / metabolism*
Intensive Care Units
Nutrition Therapy*
Parenteral Nutrition*
Reg. No./Substance:
0/Amino Acids

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