| Nutritional supplements for age-related macular degeneration. | |
| | |
MedLine Citation:
|
PMID: 20216418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Age-related macular degeneration (AMD), a leading cause of visual loss in older adults, has limited therapeutic options. This review describes the current literature on the role of nutritional supplementation in primary and secondary prevention of AMD. RECENT FINDINGS: Many observational studies have explored the association between diet, nutrient intake, and AMD. In particular, high dietary intakes of omega-3 fatty acids, and macular xanthophylls lutein and zeaxanthin have been associated with a lower risk of prevalent and incident AMD. However, the Age-Related Eye Disease study (AREDS) is the only large-scale randomized controlled clinical trial to show a 25% beneficial effect of nutritional supplementation in reducing the risk progression to advanced AMD in patients with intermediate AMD or with advanced AMD in one eye at 5 years of follow-up. On the basis of the results of AREDS, these patients are recommended to take AREDS formulation of vitamins C, E, beta-carotene, and zinc with copper. SUMMARY: At the present time, there is insufficient evidence in the literature to recommend routine nutritional supplementation in healthy adults for primary prevention of AMD. However, patients with intermediate risk of AMD or advanced AMD in one eye should consider taking AREDS-type supplements. Observational studies have also suggested benefit from increased dietary intake of macular xanthophylls and omega-3 fatty acids. These are currently being evaluated prospectively in a randomized controlled clinical trial, the AREDS2. |
| | |
Authors:
|
Nupura Krishnadev; Annal D Meleth; Emily Y Chew |
Related Documents
:
|
7354968 - Resurgence of nutritional rickets associated with breast-feeding and special dietary pr... 1802218 - Multi-trace-element supplementation in enteral formulas for burned guinea pigs. 19501248 - Nutritional treatment of obesity. 22203338 - Glucose and lipid metabolism in the pancreas of rainbow trout is regulated at the molec... 8863008 - Meal frequency; does it determine postprandial lipaemia? 10358 - Effects of stock or purified diet on rat liver enzymes involved in the synthesis of dim... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current opinion in ophthalmology Volume: 21 ISSN: 1531-7021 ISO Abbreviation: Curr Opin Ophthalmol Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-15 Completed Date: 2010-05-28 Revised Date: 2012-03-08 |
Medline Journal Info:
|
Nlm Unique ID: 9011108 Medline TA: Curr Opin Ophthalmol Country: United States |
Other Details:
|
Languages: eng Pagination: 184-9 Citation Subset: IM |
Affiliation:
|
National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antioxidants
/
administration & dosage Fatty Acids, Omega-3 / administration & dosage Humans Lutein / administration & dosage Macular Degeneration / prevention & control* Nutritional Support* Vitamins / administration & dosage Xanthophylls / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
|
Z99 EY999999/EY/NEI NIH HHS; ZIE EY000487-01/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Fatty Acids, Omega-3; 0/Vitamins; 0/Xanthophylls; 127-40-2/Lutein; 144-68-3/zeaxanthin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evidence-based cesarean technique.
Next Document: Pharmacologic treatment of atrophic age-related macular degeneration.