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Nutritional supplementation assessment with whey proteins and TGF-β in patients with Crohn's disease.
MedLine Citation:
PMID:  23165575     Owner:  NLM     Status:  In-Data-Review    
Crohn's disease (CD) is a chronic inflammatory disorder that primarily affects the intestines, resulting in breakage of the intestinal barrier, pathological inflammation and nutritional disorders that encompass from trace elements deficiency to severe malnutrition. Nutritional interventions either alone or associated to drug therapy may be effective to achieve and maintain inflammation remission. Objective: To evaluate usual food intake as quantitative and qualitatively, in CD patients; and describe the effect of a supplement containing whey proteins and TGF- on their body composition. Patients and methods: Dietary intake was assessed considering 42 consecutive patients, followed in a tertiary center, and by using the 3-day food recall and food intake frequency questionnaire. Body composition was assessed previously and 8 weeks after supplementation with a diet containing whey proteins and TGF-β (N = 22). Results and discussion: Considering carbohydrates and lipids, most patients had adequate dietary intake according recommendations. Protein, saturated fat, B12 vitamin and zinc intakes were higher than the recommended values. The dietary fiber, A, D, C and E vitamins, calcium, iron, folate, potassium and sodium intakes did not reach the recommended requirements in most patients. Patients supplemented with the whey protein and TGF-β dietary presented a positive increment in their lean body mass, when compared to non-supplemented group. Conclusion: CD patients require nutritional orientation. Whey protein intake resulted in significant differences, such as improvement in Lean Body Mass and reduction in Fat percentage.
T Davanço; V Oya; C Saddy Rodrigues Coy; R Franco Leal; M de L Setsuko Ayrizono; V C Sgarbieri; M M Dos Santos Vilela; E A Lomazi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral     Volume:  27     ISSN:  1699-5198     ISO Abbreviation:  Nutr Hosp     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100365     Medline TA:  Nutr Hosp     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  1286-92     Citation Subset:  IM    
Centre for Research in Pediatrics and Pediatrics Department, School of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Brazil.
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