Document Detail

Nutritional status of zinc and activity superoxide dismutase in chronic renal patients undergoing hemodialysis.
MedLine Citation:
PMID:  22411396     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Chronic kidney disease promotes changes in the zinc nutritional status and in the antioxidant defense system. This study assessed the relationship between the parameters of the zinc nutritional status and the activity of superoxide dismutase in patients with chronic renal failure who are receiving hemodialysis.
METHODS: 134 individuals, aged between 18 and 85 years, were divided into two groups: case group (hemodialyzed patients, n = 63) and control group (n = 71). Zinc concentrations in plasma and erythrocytes were determined using the flame atomic absorption spectrophotometry technique. The activity of superoxide dismutase enzyme was determined according to Ransod kit.
RESULTS: The mean values of plasma zinc were 62.02 ± 13.59 μg/dL and 65.58 ± 8.88 μg/dL, and for erythrocytary zinc the values were 54.52 ± 22.82 μgZn/gHb and 48.01 ± 15.08 μgZn/gHb for the chronic renal patients and the control group, respectively. The activity of superoxide dismutase was significantly lower in patients when compared with the control group (p < 0.05).
CONCLUSION: The activity of superoxide dismutase in patients with chronic renal failure undergoing hemodialysis, which is influenced by zinc concentracions, was significantly lower. There was an inadequate response of this enzyme to oxidative stress in patients undergoing hemodialysis.
R C Noleto Magalhães; C Guedes Borges de Araujo; V Batista de Sousa Lima; J Machado Moita Neto; N do Nascimento Nogueira; D do Nascimento Marreiro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrición hospitalaria     Volume:  26     ISSN:  1699-5198     ISO Abbreviation:  Nutr Hosp     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-07-03     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9100365     Medline TA:  Nutr Hosp     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  1456-61     Citation Subset:  IM    
Departamento de Ciencias de Salud, Universidad Federal del Piauí, Teresina, Piauí, Brasil.
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MeSH Terms
Aged, 80 and over
Cross-Sectional Studies
Erythrocytes / chemistry
Kidney Failure, Chronic / metabolism*,  therapy*
Middle Aged
Nutritional Status*
Plasma / chemistry
Reactive Oxygen Species / metabolism
Renal Dialysis*
Spectrophotometry, Atomic
Superoxide Dismutase / metabolism*
Young Adult
Zinc / blood,  metabolism*
Reg. No./Substance:
0/Reactive Oxygen Species; 7440-66-6/Zinc; EC Dismutase

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