| Nutritional status of selenium in Alzheimer's disease patients. | |
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MedLine Citation:
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PMID: 19948078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies have shown that various antioxidants are decreased in different age-related degenerative diseases and thus, oxidative stress would have a central role in the pathogenesis of many disorders that involve neuronal degeneration, including Alzheimer's disease (AD). The present study aimed to assess the nutritional status of Se in AD patients and to compare with control subjects with normal cognitive function. The case-control study was carried out on a group of elderly with AD (n 28) and compared with a control group (n 29), both aged between 60 and 89 years. Se intake was evaluated by using a 3-d dietary food record. Se was evaluated in plasma, erythrocytes and nails by using the method of hydride generation atomic absorption spectroscopy. Deficient Se intake was largely observed in the AD group. AD patients showed significantly lower Se levels in plasma, erythrocytes and nails (32.59 microg/l, 43.74 microg/l and 0.302 microg/g) when compared with the control group (50.99 microg/l, 79.16 microg/l and 0.400 microg/g). The results allowed us to suggest that AD has an important relation with Se deficiency. |
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Authors:
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B?rbara Rita Cardoso; Thomas Prates Ong; Wilson Jacob-Filho; Omar Jaluul; Maria Isabel d'Avila Freitas; Silvia M Franciscato Cozzolino |
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Publication Detail:
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Type: Journal Article Date: 2009-12-01 |
Journal Detail:
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Title: The British journal of nutrition Volume: 103 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 803-6 Citation Subset: IM |
Affiliation:
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PRONUT (Program of Applied Human Nutrition)-FSP/FCF/FEA, Faculty of Pharmaceutical Sciences, University of S?o Paulo (USP), S?o Paulo, Brazil. barbaracardoso@usp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / blood* Case-Control Studies Diet Erythrocytes / chemistry Female Humans Male Nails / chemistry Nutritional Status* Selenium / administration & dosage, analysis, blood* Spectrophotometry, Atomic |
| Chemical | |
Reg. No./Substance:
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7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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