| Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds. | |
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MedLine Citation:
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PMID: 20156422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sweet taste usually signifies the presence of caloric food. It is commonly accepted that a close association exists among sweet taste perception, preference, and nutritional status. However, the mechanisms involved remain unknown. To investigate whether nutritional status affects the preference for palatable solutions and alters sweet taste receptor gene expression in rats, we measured saccharin intake and preference using a two-bottle preference test, and changes in body weight, plasma leptin levels, and gene expression for the sweet taste receptor in taste buds in high-fat diet-induced obese rats and chronically diet-restricted rats. We found that the consumption and preference ratios for 0.01 and 0.04 M saccharin were significantly lower in the high-fat diet-induced obese rats than in the normal diet rats, while the serum leptin levels were markedly increased in obese rats. Consistent with the changes in saccharin intake, the gene expression level of the sweet taste receptor T1R3 was significantly decreased in the high-fat diet-induced obese rats compared with the control rats. By contrast, the chronically diet-restricted rats showed remarkably enhanced consumption and preference for 0.04 M saccharin. The serum leptin concentration was decreased, and the gene expression of the leptin receptor was markedly increased in the taste buds. In conclusion, our results suggest that nutritional status alters saccharin preference and the expression of T1R3 in taste buds. These processes may be involved in the mechanisms underlying the modulation of peripheral sweet taste sensitivity, in which leptin plays a role. |
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Authors:
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Ke Chen; Jianqun Yan; Yi Suo; Jinrong Li; Qian Wang; Bo Lv |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-12 |
Journal Detail:
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Title: Brain research Volume: 1325 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 53-62 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Physiology and Pathophysiology, Xian Jiaotong University School of Medicine, Xian, Shaanxi, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / physiology Diet* Dietary Fats / administration & dosage Feeding Behavior / physiology* Food Deprivation / physiology Food Preferences / physiology* Gene Expression Leptin / blood Male Obesity / blood, physiopathology RNA, Messenger / metabolism Random Allocation Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled / genetics, metabolism* Saccharin* Taste Buds / physiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Leptin; 0/RNA, Messenger; 0/Receptors, G-Protein-Coupled; 0/taste receptors, type 1; 81-07-2/Saccharin |
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