| Nutritional status affects branched-chain oxoacid dehydrogenase activity during exercise in humans. | |
MedLine Citation:
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PMID: 9124328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effect of glycogen availability and branched-chain amino acid (BCAA) supplementation on branched-chain oxoacid dehydrogenase (BCOAD) activity during exercise. Six subjects cycled at approximately 75% of their maximal oxygen uptake to exhaustion on three occasions under different preexercise conditions: 1) low muscle glycogen (LOW), 2) low muscle glycogen plus BCAA supplementation (LOW+BCAA), and 3) high muscle glycogen (CON). The LOW trial was performed first, followed by the other two conditions in random order, and biopsies for all trials were obtained at rest, after 15 min of exercise (15 min), and at the point of exhaustion during the LOW trial (49 min). BCOAD activity was not different among the three conditions at rest; however, at 15 min BCOAD activity was higher (P < or = 0.05) for the LOW (31 +/- 5%) and LOW+BCAA (43 +/- 11%) conditions compared with CON (12 +/- 1%). BCOAD activity at 49 min was not different from respective values at 15 min for any condition. These data indicate that BCOAD is rapidly activated during submaximal exercise under conditions associated with low carbohydrate availability. However, there was no relationship between BCOAD activity and glycogen concentration or net glycogenolysis, which suggests that factors other than glycogen availability are important for BCOAD regulation during exercise in humans. |
Authors:
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M L Jackman; M J Gibala; E Hultman; T E Graham |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 272 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-04-24 Completed Date: 1997-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E233-8 Citation Subset: IM |
Affiliation:
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Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) Adult Amino Acids / metabolism Bicycling Blood / metabolism Exercise* Female Glycogen / metabolism Heart / physiology Humans Ketone Oxidoreductases / metabolism* Male Multienzyme Complexes / metabolism* Muscle, Skeletal / metabolism Nutritional Status* Respiration |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Multienzyme Complexes; 9005-79-2/Glycogen; EC 1.2.-/Ketone Oxidoreductases; EC 1.2.4.4/3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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