Document Detail

Nutritional requirements for detoxication of environmental chemicals.
MedLine Citation:
PMID:  1778274     Owner:  NLM     Status:  MEDLINE    
The biological defence systems against oxygen radical toxicity and chemical toxicity, and their component enzymes, are described, and the nutritional requirements for biological defence against chemical and oxygen toxicity, including calories, protein, lipids and lipotropes, vitamins and minerals, are reviewed in the context of their contribution to the mechanisms of detoxication. Modulation of the cytochromes P-450, and hence toxicity, by dietary components are considered; the P450I family, induced by food pyrolysis mutagens, and the P450IIE family, induced by alcohol and fasting, contribute substantially to chemical toxicity and carcinogenicity. It is concluded that: (i) the detoxication system of terrestrial fauna has evolved over greater than 300 million years to protect animals from dietary plant toxins; (ii) protection against chemical and oxygen toxicity requires all categories of nutrients; and (iii) the rôle of food and nutrition in detoxication is essential to survival.
D V Parke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Food additives and contaminants     Volume:  8     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  381-96     Citation Subset:  IM; S    
School of Biological Sciences, University of Surrey, Guildford, UK.
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MeSH Terms
Cytochrome P-450 Enzyme System / metabolism
Metabolic Detoxication, Drug*
Nutritional Physiological Phenomena*
Oxygen / toxicity
Reg. No./Substance:
7782-44-7/Oxygen; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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