| Nutritional requirements for detoxication of environmental chemicals. | |
| | |
MedLine Citation:
|
PMID: 1778274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The biological defence systems against oxygen radical toxicity and chemical toxicity, and their component enzymes, are described, and the nutritional requirements for biological defence against chemical and oxygen toxicity, including calories, protein, lipids and lipotropes, vitamins and minerals, are reviewed in the context of their contribution to the mechanisms of detoxication. Modulation of the cytochromes P-450, and hence toxicity, by dietary components are considered; the P450I family, induced by food pyrolysis mutagens, and the P450IIE family, induced by alcohol and fasting, contribute substantially to chemical toxicity and carcinogenicity. It is concluded that: (i) the detoxication system of terrestrial fauna has evolved over greater than 300 million years to protect animals from dietary plant toxins; (ii) protection against chemical and oxygen toxicity requires all categories of nutrients; and (iii) the rôle of food and nutrition in detoxication is essential to survival. |
| | |
Authors:
|
D V Parke |
Related Documents
:
|
18963804 - Separation and determination of arsenic(v) and arsenic(iii) in sea-water by solvent ext... 11971644 - Combined effects of algal (chlorella vulgaris) density and ammonia concentration on the... 11886184 - Food concentration affects the life history response of ceriodaphnia cf. dubia to chemi... 10828504 - Subchronic (90-day) toxicity study in rats fed gum kondagogu (cochlospermumgossypium). 20388054 - Micronutrients and women of reproductive potential: required dietary intake and consequ... 2757784 - Qualitative and quantitative analyses of hoarding in medial frontal cortex rats using a... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Food additives and contaminants Volume: 8 ISSN: 0265-203X ISO Abbreviation: Food Addit Contam Publication Date: 1991 May-Jun |
Date Detail:
|
Created Date: 1992-03-12 Completed Date: 1992-03-12 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8500474 Medline TA: Food Addit Contam Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 381-96 Citation Subset: IM; S |
Affiliation:
|
School of Biological Sciences, University of Surrey, Guildford, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cytochrome P-450 Enzyme System / metabolism Humans Metabolic Detoxication, Drug* Nutritional Physiological Phenomena* Oxygen / toxicity |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Food surveillance in the Basque country (Spain) I. The design of a total diet study.
Next Document: Dowel cores, traditional and alternative. Bond test