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Nutritional regulation of glucokinase: a cross-species story.
MedLine Citation:
PMID:  24896238     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The glucokinase (GK) enzyme (EC 2.7.1.1.) is essential for the use of dietary glucose because it is the first enzyme to phosphorylate glucose in excess in different key tissues such as the pancreas and liver. The objective of the present review is not to fully describe the biochemical characteristics and the genetics of this enzyme but to detail its nutritional regulation in different vertebrates from fish to human. Indeed, the present review will describe the existence of the GK enzyme in different animal species that have naturally different levels of carbohydrate in their diets. Thus, some studies have been performed to analyse the nutritional regulation of the GK enzyme in humans and rodents (having high levels of dietary carbohydrates in their diets), in the chicken (moderate level of carbohydrates in its diet) and rainbow trout (no carbohydrate intake in its diet). All these data illustrate the nutritional importance of the GK enzyme irrespective of feeding habits, even in animals known to poorly use dietary carbohydrates (carnivorous species).
Authors:
Stéphane Panserat; Nicole Rideau; Sergio Polakof
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-4
Journal Detail:
Title:  Nutrition research reviews     Volume:  -     ISSN:  1475-2700     ISO Abbreviation:  Nutr Res Rev     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9113797     Medline TA:  Nutr Res Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-27     Citation Subset:  -    
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