Document Detail

Nutritional and prognostic significance of insulin-like growth factor 1 in patients with liver cirrhosis.
MedLine Citation:
PMID:  9131676     Owner:  NLM     Status:  MEDLINE    
Most of the traditional parameters for nutrition assessment have important limitations in patients with chronic liver disease. Insulin-like growth factor 1 (IGF-1) has been found to be regulated by nutrition and proposed as a nutritional marker. Its nutritional significance in patients with liver cirrhosis, however, has not been investigated. Serum IGF-1 as well as traditional anthropometric, visceral, and immunologic parameters were evaluated in 64 hospitalized cirrhotics, followed up clinically for 2 y. IGF-1Z-score averaged -2.16 +/- 1.08 and inversely correlated with Child-Pugh score (P < 0.01), the most reliable composite score reflecting the severity of liver disease. IGF-1Z-score was not different in patients with or without signs of energy malnutrition, as defined by values of midarm muscle circumference (MAMC) and/or triceps skinfold (TSF) < 5th percentile. Moreover, IGF-1Z-score did not correlate with MAMC or TSF. Despite its correlation with all visceral proteins, the reduction of IGF-1 was much greater and more frequent than that of visceral proteins. Patients with IGF-1Z-score < median values (-2.5) showed lower long-term survival rates compared with patients with IGF-1Z-score > -2.5 (P < 0.01). These data indicate that serum IGF-1 is not related to energy malnutrition in cirrhotic patients, while it appears to be a good predictor of survival and an early marker of liver dysfunction. Multiple factors, most of which are related to the severity of the liver disease, may contribute to the reduction of IGF-1. This multifactorial pathogenesis probably accounts for its prognostic significance.
L Caregaro; F Alberino; P Amodio; C Merkel; P Angeli; M Plebani; M Bolognesi; A Gatta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  13     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-08-14     Completed Date:  1997-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, University of Padua, Italy.
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MeSH Terms
Biological Markers / blood
Cohort Studies
Insulin-Like Growth Factor I / analysis*
Liver Cirrhosis / blood*,  mortality,  physiopathology
Middle Aged
Nutrition Assessment
Nutritional Status / physiology*
Prealbumin / analysis
Serum Albumin / analysis
Severity of Illness Index
Survival Analysis
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Prealbumin; 0/Serum Albumin; 67763-96-6/Insulin-Like Growth Factor I
Comment In:
Nutrition. 1997 Mar;13(3):231-2   [PMID:  9131686 ]

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