Document Detail


Nutritional and pharmacological enhancement of gut-associated lymphoid tissue.
MedLine Citation:
PMID:  11110628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There has been an explosion of research in the field of nutrition over the past quarter century. Clinical studies have demonstrated the effectiveness of providing nutrition by the enteral route in reducing septic morbidity in critically ill patients. These improved outcomes have been substantiated by animal models that show that enteral nutrition decreases gut permeability while maintaining the gut-associated lymphoid tissue (GALT) in mucosal immunity. Evidence points to the important immunological role of the gut in the maintenance of mucosal immunity at both intestinal and extraintestinal sites. The preservation of this mucosal immunity by enteral nutrition is consistent with the lower morbidity seen in severely injured patients who receive nutrition via the gastrointestinal tract. For patients who are unable to be fed by the enteral route and who require parenteral nutrition, several supplements show promise in enhancing the mucosal immune system defenses. The nutritional and pharmacological tactics that may enhance the GALT and thereby maintain mucosal immunity are examined.
Authors:
M K Hanna; K A Kudsk
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Canadian journal of gastroenterology = Journal canadien de gastroenterologie     Volume:  14 Suppl D     ISSN:  0835-7900     ISO Abbreviation:  Can. J. Gastroenterol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-16     Completed Date:  2001-02-01     Revised Date:  2014-01-17    
Medline Journal Info:
Nlm Unique ID:  8807867     Medline TA:  Can J Gastroenterol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  145D-151D     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Translocation
Bombesin / pharmacology
Critical Illness
Disease Models, Animal
Enteral Nutrition*
Glutamine / pharmacology
Humans
Immunity, Mucosal*
Intestinal Mucosa / immunology
Intestines / immunology*
Lymphoid Tissue / immunology*
Parenteral Nutrition
Grant Support
ID/Acronym/Agency:
5R016M53439//PHS HHS
Chemical
Reg. No./Substance:
0RH81L854J/Glutamine; PX9AZU7QPK/Bombesin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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